System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Studies

Observational Recruiting

NCT05833607 on ClinicalTrials.gov

Effects of Targets of Blood Pressure on Cerebral Hemodynamics in Septic Shock

Official title: Effects of Systemic Blood Pressure Targets on Cerebral Hemodynamics in Septic Shock: a Prospective Study

  • Sponsor: D’Or Institute for Research and Education
  • Enrollment: 40 (Estimated)
  • Study start: 2022-07-07 (Actual)
  • Primary completion: 2023-12-30 (Estimated)
  • Study completion: 2024-07-07 (Estimated)
  • Allocation: N/a
  • InterventionModel: N/a
  • Masking: None
  • PrimaryPurpose: Other

Brief Summary

The sudy objective is to evaluate the cerebral haemodynamic status in different ranges of systemic arterial pressure in patients with septic shock by noninvasive tools, transcranial doppler and intracranial compliance by mechanical sensor (B4C).

Patients participating in the study will be submitted to different levels of arterial pressure, titrated with vasopressor and them their cerebral hemodynamic variables will be evaluated,

Conditions

  • Septic Shock
  • Cerebral Autoregulation

Primary Outcome Measures

  • The primary objective is to evaluate the effects of cerebral haemodynamic in patients with septic shock in different targets of MAP, through ARI (by Transcranial Doppler), and intracranial compliance by mechanical sensor (B4C) (Data will be obtained at the time of collection (mean arterial pressure targets) and subsequently analyzed)
    This outcome will be analyzed by transcranial Doppler (ARI, PI) and B4C (intracranial compliance) index). Data will be obtained at the time of collection (mean arterial pressure targets) and subsequently analyzed

Countries

Brazil

Locations and Investigators

  • SĂ£o Rafael Hospital, Salvador, Brazil (Recruiting)
    • Juliana Caldas
    • Pedro Cury

Study Officials