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Studies

Observational Active not recruiting

NCT05898165 on ClinicalTrials.gov

Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study

Official title: Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study of a Risk Score for Early Detection of Atrial Fibrillation

  • Sponsor: University of Leeds
  • Collaborators: British Heart Foundation, Daiichi Sankyo, The Leeds Teaching Hospitals NHS Trust
  • Enrollment: 1955 (Estimated)
  • Study start: 2023-10-01 (Actual)
  • Primary completion: 2025-06-16 (Actual)
  • Study completion: 2033-02-28 (Estimated)
  • Allocation: N/a
  • InterventionModel: N/a
  • Masking: None
  • PrimaryPurpose: Other

Brief Summary

The purpose of this study is to trial a new intervention - risk-guided AF screening using an EHR-based risk score and remote ECG monitoring process - and to characterise individuals at elevated predicted AF risk.

Conditions

  • Atrial Fibrillation
  • Heart Diseases
  • Cardiovascular Diseases

Intervention / Treatment

  • Other: Development of an algorithm

Primary Outcome Measures

  • To determine whether detection rates of AF during ECG monitoring are higher amongst participants identified as higher risk of AF, compared with those identified as lower risk (6 months)
    Rate ratio of AF detection rates during ECG monitoring in participants identified as higher risk by FIND-AF compared with participants identified as lower risk
  • To determine whether detection rates of AF during ECG monitoring are higher amongst participants identified as higher risk of AF, compared with those identified as lower risk (5 years)
    Rate ratio of AF detection rates during ECG monitoring in participants identified as higher risk by FIND-AF compared with participants identified as lower risk
  • To determine whether detection rates of AF during ECG monitoring are higher amongst participants identified as higher risk of AF, compared with those identified as lower risk (10 years)
    Rate ratio of AF detection rates during ECG monitoring in participants identified as higher risk by FIND-AF compared with participants identified as lower risk

Countries

United Kingdom

Locations and Investigators

  • University of Leeds, Leeds, United Kingdom

Study Officials

  • Chris Gale, Yes (Principal Investigator) — University of Leeds