Interventional Recruiting
NCT06013579 on ClinicalTrials.gov
Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV
Official title: Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV (HEALTH-Cog)
- Sponsor: University of Alabama at Birmingham
- Collaborators: University of Colorado, Denver, University of Washington, National Institute on Aging (NIA)
- Enrollment: 110 (Estimated)
- Study start: 2023-08-01 (Actual)
- Primary completion: 2027-09-01 (Estimated)
- Study completion: 2028-03-01 (Estimated)
- Allocation: Randomized
- InterventionModel: Parallel
- Masking: Double (Investigator, Outcomes Assessor)
- PrimaryPurpose: Prevention
Brief Summary
People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implications for development of personalized approaches for the treatment and prevention of cognitive impairment and dementia in older people with HIV.
Conditions
- HIV Infections
- Cognitive Impairment
Intervention / Treatment
- Behavioral: Phase 1 Gym Exercise HIIT
- Behavioral: Phase 1 Gym Exercise CME
- Behavioral: Phase 2 Home Exercise Coaching Text Messages
- Behavioral: Phase 2 Home Exercise Control Text Messages
Primary Outcome Measures
-
Cognition
(Baseline visit)
Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning. -
Cognition
(4 month follow-up visit)
Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning. -
Cognition
(7 month follow-up visit)
Cognitive assessment battery test speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning. -
Cognition
(12 month follow-up visit)
Cognitive assessment battery tests speed of processing, learning, memory, executive functioning, verbal fluency, working memory, motor, subjective cognitive complaints, and everyday functioning.
Countries
United States
Locations and Investigators
-
University of Alabama at Birmingham, Birmingham, United States (Not yet recruiting)
- Pariya Wheeler, PhD
-
University of Colorado Denver, Aurora, United States (Recruiting)
- Kristine Erlandson, MD
- University of Washington, Seattle, United States (Recruiting)