Interventional Recruiting Phase 2/Phase 3
NCT06083948 on ClinicalTrials.gov
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
Official title: Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia in Neurosurgical Patients
- Sponsor: Aarhus University
- Enrollment: 32 (Estimated)
- Study start: 2023-12-20 (Actual)
- Primary completion: 2027-12-30 (Estimated)
- Study completion: 2027-12-31 (Estimated)
- Allocation: Randomized
- InterventionModel: Parallel
- InterventionModelDescription: Randomized, double blinded, clinical trial
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- PrimaryPurpose: Treatment
Brief Summary
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.
Conditions
- Hypotension
Intervention / Treatment
- Drug: Noradrenalin
- Drug: Phenylephrine
Primary Outcome Measures
-
Cerebral blood flow
(Up to 3 hours (measured on the day of surgery prior to the surgical procedure))
Blood flow measured in milliliters per minute through selected regions of the brain as determined by Positron Emission Tomography
Countries
Denmark
Locations and Investigators
-
Aarhus University Hospital, Aarhus, Denmark (Recruiting)
- Mads Rasmussen, MD, PhD
Study Officials
- Mads Rasmussen, MD, PhD (Principal Investigator) — Aarhus University Hospital