Studies

Interventional Recruiting

NCT06361407 on ClinicalTrials.gov

Sensory and Cognitive Predictions, and Their Disruptions in Schizophrenia

  • Sponsor: Centre Psychothérapique de Nancy
  • Collaborators: Institut National de la Santé Et de la Recherche Médicale, France
  • Enrollment: 68 (Estimated)
  • Study start: 2024-06-28 (Actual)
  • Primary completion: 2027-10-28 (Estimated)
  • Study completion: 2027-10-28 (Estimated)
  • Allocation: N/a
  • InterventionModel: Single Group
  • InterventionModelDescription: Individuals with schizophrenia will be tested in parallel with neurotypicals
  • Masking: None
  • PrimaryPurpose: Basic Science

Brief Summary

Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms. Previous work has shown that patients have difficulty preparing to process information on the scale of a second, but are abnormally disturbed by slightly asynchronous information on the millisecond scale. In both cases, the anomalies could explain the patients' unusual experience of time. The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored, whereas in patients suffering from schizophrenia they would disrupt the flow of time. This hypothesis is tested with a new visual illusion.

Conditions

  • Schizophrenia
  • Sensory Processing Disorder

Intervention / Treatment

  • Behavioral: Illusion task

Primary Outcome Measures

  • Effect of a millisecond-level trajectory perturbation (Month 4)
    Change in the rate of illusion in case of a trajectory perturbation (compared to the rate of illusion in the absence of perturbation)

Countries

France

Locations and Investigators

  • CHU Sainte Marguerite, APHM, Marseille, France (Recruiting)
    • Michel CERMOLACCE, PU.PH
    • Barbara LELLOUCHE, MD (Principal Investigator)
  • Centre Hospitalier Drôme Vivarais, Montéléger, France (Recruiting)
    • Brice MARTIN, MD
    • Brice MARTIN, MD (Principal Investigator)

Study Officials