Observational Recruiting
NCT06678360 on ClinicalTrials.gov
Perioperative Impact of Physical Activity on Short- and Long-term Morbidity and Mortality
Official title: Perioperative Impact After Non-cardiac Surgery of Physical Activity on Short- and Long-term Morbidity and Mortality
- Sponsor: Karolinska Institute
- Enrollment: 180000 (Estimated)
- Study start: 2024-11-01 (Actual)
- Primary completion: 2025-08-31 (Estimated)
- Study completion: 2025-12-01 (Estimated)
- Allocation: N/a
- InterventionModel: N/a
- Masking: None
- PrimaryPurpose: Other
Brief Summary
Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.
Age and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity is associated to lower risk of perioperative morbidity and mortality.
Conditions
- General Surgery
- Perioperative Complication
- Perioperative Medicine
- Physical Inactivity
Primary Outcome Measures
-
Mortality
(Mortality will be recorded at 30, 60, 90 and 365 days after index surgery)
Death within the time frames described below -
DAH30 (Days At Home alive at 30 days)
(30, 90 and 365 days after index surgery,)
DAH30: Patients who are hospitalized for 14 days postoperatively but are alive on day 30 will have DAH30=16. Patients who are hospitalized for five days, then discharged, but return after 10 days for an additional 11-day stay, will have DAH30=14. Anyone who dies within 30 days will have DAH30=0. This outcome measure is validated in several studies and has a significant advantage in that it correlates well with complications, even better than length of stay (LOS). We will further record DAH90 and DAH365, calculated as described above.
Countries
Sweden
Locations and Investigators
-
Karolinska Institutet, Stockholm, Sweden (Recruiting)
- Max Bell, MD, PhD
- Max Bell, MD, PhD (Principal Investigator)
Study Officials
- Max Bell, MD, PhD (Principal Investigator) — Karolinska Institutet
- Arman Valadkhani, MD (Study Chair) — Karolinska Institutet