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Studies

Interventional Not yet recruiting

NCT06776393 on ClinicalTrials.gov

Longitudinal Non-invasive Analysis of VOCAle Cord Function Based on Trans-laryngeal Ultrasound Acquisitions and Voice Recordings

  • Sponsor: Assistance Publique - Hôpitaux de Paris
  • Enrollment: 100 (Estimated)
  • Study start: 2025-01-01 (Estimated)
  • Primary completion: 2025-06-01 (Estimated)
  • Study completion: 2028-01-01 (Estimated)
  • Allocation: N/a
  • InterventionModel: Single Group
  • InterventionModelDescription: patients who have undergone cervical endocrine surgery.
  • Masking: None
  • PrimaryPurpose: Other

Brief Summary

The main objective of VOCALISE study is to propose a new approach allowing a better characterization of postoperative dysphonia. This involves associating with dynamic translaryngeal ultrasound optimized acquisitions of the vibration of each vocal fold in phonation simultaneously with voice recordings. A software program to analyze the displacement of arytenoids, markers of substitution of the vocal cords, will be developed to finely quantify the mobility of laryngeal structures, by combining classical methods of motion analysis and deep learning methods.

This approach will be evaluated to follow speech therapy rehabilitation in patients with post-operative dysphonia following recurrent nerve injury.

Conditions

  • Postoperative Dysphonia

Intervention / Treatment

  • Other: ultrasound

Primary Outcome Measures

  • To evaluate the contribution of translaryngeal ultrasound combined with acoustic and perceptual measurements of voice and speech classically used in speech therapy for the rehabilitation of patients with dysphonia following surgery. (6 months)
    Correlation of each quantitative evaluation criterion proposed in ultrasound and voice and speech analysis with the classical voice quality criteria: the VHI (voice handicap index), the GRBASI scale (defined by 5 expert speech pathologists) and a set of acoustic measures of voice and speech.

Study Officials