Brief Summary

Patients with oral cavity cancer treated by reconstructive surgery with a flap.

Patients will be treated in the study for :

* Experimental arm: Post-operative radiotherapy with flap sparing
* Control arm: Standard post-operative radiotherapy without flap sparing (current practice) Radiotherapy by IMRT using photons or proton therapy (IMPT)

Conditions

• Oral Cavity Carcinoma
• Flap
• Radiotherapy, Adjuvant
• Reconstruction Surgery

Intervention / Treatment

• Radiation: Standard post-operative radiotherapy without flap sparing (current practice)
• Radiation: Post-operative radiotherapy with flap sparing

Primary Outcome Measures

• loco-regional control rate (2 years after the end of postoperative radiotherapy)
  To evaluate whether flap sparing yields non-inferior 2-year loco-regional control rate as flap-agnostic radiotherapy (as per standard routine practice) in completely resected oral cavity carcinomas undergoing postoperative radiotherapy

Countries

France

Locations and Investigators

• Chu Amiens, Amiens, France (Not yet recruiting)
  • Alexandre COUTTE
• Institut de Cancérologie de l'Ouest, Angers, France (Not yet recruiting)
  • Aurore GOINEAU
• Centre de la Baie, Avranches, France (Not yet recruiting)
  • DUMONT LECOMTE
• Centre François Baclesse, Caen, France (Recruiting)
  • Juliette THARIAT, Professor
• CHU CAEN, Caen, France (Not yet recruiting)
  • Alexis VEYSSIERE, MD
• Centre Hospitalier, Cherbourg, France (Not yet recruiting)
  • KAO
• Centre Jean Perrin, Clermont-Ferrand, France (Not yet recruiting)
  • Michel LAPEYRE
• CHIC, Créteil, France (Not yet recruiting)
  • Soumya ANANE-ABROUS, MD
• Centre Georges-François Leclerc, Dijon, France (Not yet recruiting)
  • Noémie VULQUIN, MD
• Centre Guillaume le Conquérant, Le Havre, France (Not yet recruiting)
  • Laurent MARTIN, MD
• Centre Hospitalier, Libourne, France (Not yet recruiting)
  • Muriel GARCIA RAMIREZ
• Centre Oscar Lambret, Lille, France (Not yet recruiting)
  • Ysaure ROQUETTE
• Chu Limoges, Limoges, France (Not yet recruiting)
  • SERRE
• Centre Léon Bérard, Lyon, France (Not yet recruiting)
  • Séverine RACADOT
• APHM Marseille, Marseille, France (Not yet recruiting)
  • Stéphanie WONG-HEE-KAM, MD
• Institut Régional du Cancer Val D'aurelle, Montpellier, France (Not yet recruiting)
  • Pierre BOISSELIER, MD
• Institut de Cancérologie de Lorraine, Nancy, France (Not yet recruiting)
  • Sophie RENARD
• Centre Antoine Lacassagne, Nice, France (Not yet recruiting)
  • Deborah ALOI, MD
• APHP La Pitié, Paris, France (Not yet recruiting)
  • Cyrus Chargari
• Chu Poitiers, Poitiers, France (Not yet recruiting)
  • Florent CARSUZAA
• Chu Reims, Reims, France (Not yet recruiting)
  • BRENET
• Institut Jean Godinot, Reims, France (Not yet recruiting)
  • Arnaud BEDDOCK
• Centre Eugène Marquis, Rennes, France (Not yet recruiting)
  • BATY Manon
• Centre Frédéric Joliot, Rouen, France (Not yet recruiting)
  • MARTINAGE
• Centre Henri Becquerel, Rouen, France (Not yet recruiting)
  • Ovidiu VERESEZAN
• Chu Rouen, Rouen, France (Not yet recruiting)
  • Sophie DENEUVE
• Institut de Cancérologie de l'Ouest, Saint-Herblain, France (Not yet recruiting)
  • Melanie DORE
• IUCT, Toulouse, France (Not yet recruiting)
  • Lucie PIRAM
• Chu Tours, Tours, France (Not yet recruiting)
  • Sofia BAKKAR, MD
• Institut Gustave Roussy, Villejuif, France (Not yet recruiting)
  • France NGUYEN