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Studies

Interventional Active not recruiting

NCT06855836 on ClinicalTrials.gov

Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

Official title: Efficacy and Implementation Considerations for a Peer-led Motivational Interviewing Intervention to Promote Uptake of Drug Checking Services and Safe Drug Use Behaviors to Reduce Overdose

  • Sponsor: University of California, San Diego
  • Enrollment: 588 (Actual)
  • Study start: 2025-03-03 (Actual)
  • Primary completion: 2029-02-01 (Estimated)
  • Study completion: 2029-05-01 (Estimated)
  • Allocation: Randomized
  • InterventionModel: Parallel
  • InterventionModelDescription: All recruited study participants will receive the Overdose Education and Naloxone Distribution (OEND) materials. The control group will receive additional Flu and Hepatitis A education as Group 1, and the experimental group will receive the MI-CHANCE intervention as Group 2
  • Masking: None
  • PrimaryPurpose: Prevention

Brief Summary

A hybrid type 1 study will be conducted to evaluate efficacy and preliminary implementation considerations for a novel intervention to promote uptake of drug checking services (DCS) and safer drug use behaviors among people who use drugs (PWUD) to reduce incidence of overdose (OD) and HIV and Hepatitis C virus (HCV) infections in San Diego County.

Approximately 50 syringe services programs (SSPs) in the US now offer advanced drug checking services using test strips (TS) and Fourier Transform Infrared Spectrometry (FTIR), allowing people to submit drug samples with non-nominal identifiers and obtain personalized results. While most existing FTIRs offer some counseling, no theory-based interventions to increase FTIR uptake and promote post-FTIR adoption of safer drug use behaviors have been rigorously evaluated.

Conditions

  • Overdose

Intervention / Treatment

  • Behavioral: MI-CHANCE (TS + FTIR + MI)
  • Behavioral: TS + FTIR + Flu and Hepatitis A Education

Primary Outcome Measures

  • Risk rates of fatal and non-fatal overdose over 30 months (Through study completion, an average of 30 months)
    Rate of fatal and non-fatal ODs over the course of the study (i.e., the total # of ODs that a participant experiences during the study offset by the natural log of the time spent at risk during the study). Self-reported and obtained through record linkage between MI-CHANCE and emergency medical services and the medical examiner's office to obtain data on ODs that received medical attention and OD deaths, respectively

Countries

United States

Locations and Investigators

  • MI CHANCE - Park Blvd, San Diego, United States