Brief Summary

The RING study is a European registry collecting real-world data on advanced prostate cancer (APC) imaging. It aims to evaluate the role of next-generation imaging (NGI), such as PET/CT and whole-body MRI, in detecting and monitoring the disease compared to conventional imaging.

Men aged 18 or older with histologically confirmed prostate cancer are eligible to participate in the study if they require imaging to assess potential metastases, either at diagnosis or after relapse and sign a consent form.

Patients will receive standard care with no experimental treatments. Imaging and treatment decisions will follow routine clinical practice. Data will be collected from medical records and analysed for research. This study will help doctors understand when NGI should be used, how it affects treatment decisions, and its impact on patient outcomes.

Conditions

• Prostate Cancer
• Advanced Prostate Cancer
• Metastatic Prostate Cancer (mPC)

Intervention / Treatment

• Diagnostic Test: Imaging

Primary Outcome Measures

• Proportion of patients requiring NGI, conventional imaging, or a combination of both imaging tools. (4 - 6 weeks)
  Number of patients who require NGI, conventional imaging, or a combination of both imaging tools with the respect to local protocols
• Proportion of patients with a change of treatment determined by the imaging test result, when multiple imaging tests have been realized (4-6 weeks)
  Number of patients who received multiple imaging tests for whom the result of the particular imaging test has lead to the change in management

Countries

Belgium, France, Germany, Italy, Netherlands, Poland, Spain, Sweden

Locations and Investigators

• Universitair Ziekenhuis Leuven, Leuven, Belgium (Not yet recruiting)
  • Steven Joniau, MD, Prof
  • Joniau (Principal Investigator)
• Hospital Center University De Lille, Lille, France (Not yet recruiting)
  • Arnauld Villers, MD, Prof
• Hospices Civils de Lyon, Lyon, France (Not yet recruiting)
  • Alain Ruffion, MD, Prof
  • Olivier Rouvière, MD, Prof
• University Hospitals Pitié Salpêtrière, Paris, France (Not yet recruiting)
  • Morgan Rouprêt, MD, Prof
• Bonn University Hospital, Bonn, Germany (Not yet recruiting)
  • Manuel Ritter, MD, Prof
• Martini Klinik, Hamburg, Germany (Not yet recruiting)
  • Lars Budaeus, MD, Prof
• München LMU L MU-University Clinic, Munich, Germany (Not yet recruiting)
  • Jozsefina Casuscelli, MD, Prof
  • Alexander Buchner, MD, Prof
• Urologische Klinik München - Planegg, Planegg, Germany (Not yet recruiting)
  • Martin Kriegmair, MD, Prof
• Universitätsklinik Tübingen, Tübingen, Germany (Not yet recruiting)
  • Steffen Rausch, MD
  • Igor Tsaur, MD, Prof
  • Eva Erne, MD
• IRCCS Universit of Bologna, Bologna, Italy (Not yet recruiting)
  • Lorenzo Bianchi, MD, Prof
  • Riccardo Schiav, MD, Prof
  • Stefano Fanti, MD, Prof (Principal Investigator)
• Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy (Recruiting)
  • Andrea Minervini, MD, Prof
  • Fabrizio di Maida, MD
• Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy (Not yet recruiting)
  • Sergio Serni, MD, Prof
  • Riccardo Campi, MD
• IRCCS Ospedale San Raffaele, Milano, Italy (Not yet recruiting)
  • Alberto Briganti, MD, Prof
• ERASMUS MC & Franciscus Hospital, Rotterdam, Netherlands (Not yet recruiting)
  • Rodrick van der Bergh, MD, Prof
  • Robert van Soest, MD, Prof
• Uniwersytet Jagielloński Collegium Medicum, Krakow, Poland (Not yet recruiting)
  • Piotr Chlosta, MD, Prof
  • Katarzyna Gronostaj, MD
• Fundació Puigvert, Barcelona, Spain (Recruiting)
  • Francesco Sanguedolce, MD, PhD
• Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (Recruiting)
  • Gemma Sancho, MD
• Hospital Universitario Reina Sofia, Cordoba, Spain (Not yet recruiting)
  • Enrique Gómez, MD
• Hospital Universitario La Paz, Madrid, Spain (Not yet recruiting)
  • Estefania Linares, MD
  • Mario Álvarez, MD
  • Beatriz Debén, MD
• Hospital Universitario Ramón y Cajal, Madrid, Spain (Not yet recruiting)
  • Javier Burgos Revilla, MD
  • Rodriguez Patron, MD
  • Silvia Gar, MD
• Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain (Recruiting)
  • Ana Plata, MD
  • Ana Plata, MD (Principal Investigator)
• Hospital Universitario Marqués de Valdecilla, Santander, Spain (Not yet recruiting)
  • Mario Dominguez, MD
• Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain (Not yet recruiting)
  • Danie Perez, MD
• Skånes universitetssjukhus Malmö, Malmö, Sweden (Not yet recruiting)
  • Anders Bjartell, MD, Prof

Study Officials

• Francesco Sanguedolce, MD, PhD (Study Chair) — Fundació Puigvert