Interventional Recruiting
NCT06971367 on ClinicalTrials.gov
IBIS Megastudy of Interventions to Encourage HIV Retesting
Official title: Transformative Approaches to Rapidly and Efficiently Test Demand Creation Interventions to Promote HIV Retesting in Adults at Increased Risk of HIV
- Sponsor: University of California, San Francisco
- Collaborators: University of Pennsylvania, Kenya Medical Research Institute, Infectious Diseases Research Collaboration, Uganda, University of California, Berkeley, Makerere University, National Institute of Mental Health (NIMH)
- Enrollment: 40000 (Estimated)
- Study start: 2025-12-09 (Actual)
- Primary completion: 2027-12-01 (Estimated)
- Study completion: 2027-12-01 (Estimated)
- Allocation: Randomized
- InterventionModel: Parallel
- Masking: Single (Investigator)
- PrimaryPurpose: Screening
Brief Summary
In this study, the investigators will test the effectiveness of multiple low-cost behavioral interventions, designed with end-user input, to promote HIV retesting among adults in rural Kenya and Uganda who have higher risk of HIV exposure.
Conditions
- HIV
Intervention / Treatment
- Behavioral: Risk assessment messaging
- Behavioral: U=U messaging
- Behavioral: Community benefits messaging
- Behavioral: Fresh start effect
- Behavioral: Education-based messaging
- Behavioral: Default appointment messaging
- Behavioral: Reserved for you messaging
- Behavioral: Social norms (default) messaging
- Behavioral: Social norms (varied) messaging
- Behavioral: Goal-setting messaging
- Behavioral: Incentive
Primary Outcome Measures
-
HIV retesting uptake
(Measured 3-6 months after baseline visit)
The proportion of participants in each study arm who return for repeat HIV testing within 3-6 months after the baseline visit.
Countries
Kenya, Uganda
Locations and Investigators
-
Kenya Medical Research Institution (KEMRI), Mbita, Kenya (Recruiting)
- Sabina Ogachi
- James Ayieko, MBChB, MPH, PhD (Principal Investigator)
-
Infectious Diseases Research Collaboration (IDRC), Mbarara, Uganda (Recruiting)
- Ronald Kisitu
- Moses Kamya, MBChB, MMed, PhD (Principal Investigator)
Study Officials
- Gabriel Chamie, MD, MPH (Principal Investigator) — University of California, San Francisco
- Harsha Thirumurthy, PhD (Principal Investigator) — University of Pennsylvania