Interventional Not yet recruiting
NCT07259915 on ClinicalTrials.gov
Multimodal Prediction of Response to Chemoradiotherapy for Squamous Cell Carcinoma of the Head and Neck
- Sponsor: Centre Henri Becquerel
- Enrollment: 152 (Estimated)
- Study start: 2025-12-01 (Estimated)
- Primary completion: 2030-08-01 (Estimated)
- Study completion: 2030-08-01 (Estimated)
- Allocation: N/a
- InterventionModel: Single Group
- Masking: None
- PrimaryPurpose: Diagnostic
Brief Summary
The goal of the study lies in offering a multimodal analysis of the post-therapeutic response based on both quantitative parameters and radiomics (CT, MRI, and PET imaging), and on tumor biology, in particular the hypersensitive detection of tumor DNA.
Conditions
- Squamous Cell Cancer of Head and Neck (SCCHN)
Intervention / Treatment
- Other: Multimodal approach
Primary Outcome Measures
-
Performance of multimodal approach to predict response to chemoradiation
(12 months after treatment)
Estimation of the area under the curve associated with the overall performance of the combined score established by the multimodal approach (PET/CT, MRI, CT, circulating tumor DNA, lymph node tumor DNA) in the post-CRT assessment of the status of a locoregional response within 12 months after chemoradiation.
Countries
France
Locations and Investigators
- Centre Henri Becquerel, Rouen, France
-
Centre Hospitalier Universitaire, Rouen, France
- Sophie Deneuve