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Studies

Observational Recruiting

NCT07280091 on ClinicalTrials.gov

Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome

  • Sponsor: Assistance Publique - Hôpitaux de Paris
  • Collaborators: URC-CIC Paris Descartes Necker Cochin
  • Enrollment: 30 (Estimated)
  • Study start: 2026-05-26 (Actual)
  • Primary completion: 2028-05-01 (Estimated)
  • Study completion: 2028-05-01 (Estimated)
  • Allocation: N/a
  • InterventionModel: N/a
  • Masking: None
  • PrimaryPurpose: Other

Brief Summary

It is proposed to conduct an exploratory study to analyze the skin, intestinal, and salivary microbiome, as well as the skin mycobiome and virome, of patients (adolescents and young adults) with Netherton syndrome, a condition characterized by an impaired skin barrier that most likely promotes the development of allergic manifestations.

The study will be conducted on patients with Netherton syndrome and control subjects in order to investigate possible correlation factors between the three microbiomes and identify which ones.

Conditions

  • Netherton Syndrome

Intervention / Treatment

  • Biological: Superficial skin swabs
  • Biological: Stool samples
  • Biological: Saliva samples
  • Biological: Blood samples
  • Other: Data-Collection

Primary Outcome Measures

  • Study of the skin, salivary and intestinal microbiota (Baseline)
    Analyse the skin microbiome, mycobiome, and virome, as well as the intestinal and salivary microbiome of patients with Netherton syndrome in comparison with healthy controls.

Countries

France

Locations and Investigators