System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Studies

Observational Recruiting

NCT07388173 on ClinicalTrials.gov

Functional Impact of Acute Respiratory Viral Infections in Older Adults

Official title: Assessment of Functional Impact of Acute Respiratory Viral Infections in Older Adults - An International Multi-center Study

  • Sponsor: Hôpital Albert Michallon
  • Enrollment: 1600 (Estimated)
  • Study start: 2026-01-15 (Actual)
  • Primary completion: 2028-01-15 (Estimated)
  • Study completion: 2028-06-15 (Estimated)
  • Allocation: N/a
  • InterventionModel: N/a
  • Masking: None
  • PrimaryPurpose: Other

Brief Summary

The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide. Immunosenescence and environmental exposures increase susceptibility to infection and reduce vaccine effectiveness in this population. Respiratory viruses, including influenza, SARS-CoV-2, respiratory syncytial virus, and human metapneumovirus, account for a substantial share of this burden, much of which is vaccine-preventable. However, their impact on functional decline and recovery in older adults remains insufficiently characterized. This international study aims to assess the effect of hospitalization for major respiratory viral infections on loss of autonomy in individuals aged 60 years and older, to inform targeted prevention and vaccination strategies.

Conditions

  • Respiratory Infections in Old Age

Primary Outcome Measures

  • Evolution of Functional Dependency assessed by Activities of Daily Living (ADL) Score (Baseline, at hospital discharge, 3 months after discharge, and 6 months after discharge.)
    Change in functional performance measured using the Activities of Daily Living (ADL) scale. The ADL score ranges from 0 to 6, where higher scores indicate better functional independence The ADL score ranges from 0 to 6, where higher scores indicate better functional independence.
  • Evolution of Functional Dependency assessed by Instrumental Activities of Daily Living (IADL) Score (Baseline, Day 7, 3 months after discharge, and 6 months after discharge.)
    Change in functional performance measured using the Instrumental Activities of Daily Living (IADL) scale. The IADL score ranges from 0 to 8, where higher scores indicate better functional independence.

Countries

France, Germany, Italy, Spain, United States

Locations and Investigators

  • University of Rochester School of Medicine, Infectious Diseases Unit, Rochester, United States (Recruiting)
    • Edward Walsh, MD PhD
  • University Hospital of Amiens, Amiens, France (Active not recruiting)
  • Melun Hospital, Melun, France (Recruiting)
    • Sylvain DIAMANTIS, MD
  • Villeneuve Saint Georges Hospital, Paris, France (Active not recruiting)
  • University Hospital of Poitiers, Poitiers, France (Active not recruiting)
  • University Hospital of Reims, Reims, France (Active not recruiting)
  • University Hospital of Tours, Tours, France (Active not recruiting)
  • Klinikum Bayreuth, Klinik für Geriatrie, Bayreuth, Germany (Not yet recruiting)
    • Hans-Jürgen Heppner, MD PhD
  • Abteilung Geriatrie Universitätsmedizin Göttingen, Abteilung Geriatrie, Göttingen, Germany (Not yet recruiting)
    • Christine Von Arnim, MD PhD
  • Uniklinikum Jena, Klinik für Geriatrie, Jena, Germany (Not yet recruiting)
    • Kristin Häseler-Ouart, MD
  • Universitätsmedizin Mannheim, IV. Medizinische Klinik (Geriatrie), Mannheim, Germany (Not yet recruiting)
    • Heinrich Burkhardt, MD PhD
  • Klinikum Ulm, Geriatrisches Zentrum Agaplesion Bethesda, Ulm, Germany (Not yet recruiting)
    • Michael Denkinger, MD PhD
  • University of Bari, Bari, Bari, Italy (Not yet recruiting)
    • Francesco Di Gennaro, MD
  • Azienda Ospedaliero Universitaria "Renato Dulbecco", Catanzaro, Catanzaro, Italy (Not yet recruiting)
    • Elvira Bonacci, MD
  • ULSS 5 Polesana, Rovigo, Rovigo, Italy (Not yet recruiting)
    • Pierluigi Dal Santo, MD
  • ASL 1 Imperiese, Sanremo, Sanremo, Italy (Not yet recruiting)
    • Giovanni Cenderello, MD
  • Città di Torino, Torino, Torino, Italy (Not yet recruiting)
    • Antonino Maria Cotroneo, MD
  • APSS Trento, Geriatria, Trento, Trento, Italy (Not yet recruiting)
    • Anna Casanova, MD
  • ASUGI, Trieste, Trieste, Italy (Not yet recruiting)
    • Michela Zanetti, MD
  • ULSS 3 Serenissima, Venice, Venice, Italy (Not yet recruiting)
    • Ernesto Rampin, MD
  • ULSS 9 Scaligera, Legnago, Verona, Verona, Italy (Not yet recruiting)
    • Margherita Azzini, MD
  • Hospital Clínic Barcelona Servicio de Geriatría, Barcelona, Spain (Recruiting)
    • Juan Manuel Pérez Castejón, MD
  • Hospital Universitario Ramón y Cajal. Madrid Servicio de Geriatría, Madrid, Spain (Not yet recruiting)
    • Alfonso J. Cruz Jentoft, MD
  • Hospital Universitario Virgen de la Arrixaca Murcia Servicio de Geriatría, Murcia, Spain (Not yet recruiting)
    • Juan Dionisio Avilés Hernández, MD