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Studies

Interventional Not yet recruiting Phase 2

NCT07668674 on ClinicalTrials.gov

Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis

Official title: Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis: a Multicenter Comparative Pilot Study

  • Sponsor: Centre Hospitalier Universitaire de Clermont-Ferrand
  • Enrollment: 60 (Estimated)
  • Study start: 2026-07-01 (Estimated)
  • Primary completion: 2028-08-01 (Estimated)
  • Study completion: 2028-08-01 (Estimated)
  • Allocation: Non-Randomized
  • InterventionModel: Parallel
  • Masking: None
  • PrimaryPurpose: Basic Science

Brief Summary

Some people with knee osteoarthritis (gonarthrosis) experience pain differently. In some, the pain is described as "nociceptive" (directly related to the joint), while in others it has "neuropathic" characteristics (related to nerve function).

The goal of this multicenter, cross-sectional and comparative study is to compare resting brain activity in a brain region called the anterior insula among female patients with painful knee osteoarthritis who experience nociceptive pain compared to those with neuropathic pain.

Researchers will compare brain activity at rest between these two types of pain in women over 40 with painful knee osteoarthritis. A better understanding could help improve pain management in the future.

Participants will be asked to :

* complete questionnaires during the inclusion visit and on the day of the scan,
* undergo a clinical examination and a blood test at the inclusion visit,
* undergo a functional MRI (fMRI), an imaging test that allows observation of brain activity at rest.

Paticipants in the study does not involve any additional treatment. the fMRI scan is non-invasive and does not require any injections.

Conditions

  • Gonarthrosis
  • Neuropathic Pain, Nociceptive Pain

Intervention / Treatment

  • Biological: blood sampling
  • Procedure: Resting-state functional MRI

Primary Outcome Measures

  • Resting-state anterior insula activity measured by functional MRI (BOLD signal amplitude) (At Visit 2 : within 30 days after inclusion, following Visit 1)
    Comparison of resting-state anterior insula brain activity between patients with painful knee osteoarthritis with nociceptive pain and those with neuropathic-like pain, classified using the painDETECT questionnaire.

Countries

France

Locations and Investigators

  • CHU Clermont-Ferrand, Clermont-Ferrand, France
  • APHP - Pitié-Salpêtrière, Paris, France
    • Florian BAILLY
    • Florian BAILLY (Principal Investigator)
  • APHP - Saint-Antoine, Paris, France
    • Jérémie SELLAM
    • Jérémie SELLAM (Principal Investigator)

Study Officials