Gen Ohtsuki is a program-specific Professor at Kyoto University Graduate School of Medicine. He graduated as a B.S., Kyoto University, Japan (2002) and received his Ph.D. in 2007 from Kyoto University Graduate School of Science, Japan, which was followed by postdoctoral researches at Erasmus University Medical Center, Department of Neuroscience, the Netherlands (2007-2008) and at the University of Chicago, Department of Neurobiology, USA (2008-2011). From 2006 to 2007, he received the researcher fellowship for Young Scientists of JSPS. He worked as a program-specific Assistant professor at Kyushu University, Graduate School of Medical Sciences, Japan (2011 to 2015). Then, he joined the Hakubi-project (Kyoto University) as an independent program-specific Associate Professor (2015 to 2020) and moved to Kyoto University Graduate School of Medicine in 2020. He revealed several forms of the plasticity in the cerebellar Purkinje cells at developmental climbing-fiber synapses, firing increase plasticity and associated changes, and excitability plasticity of the dendrites (Ohtsuki & Hirano, 2008 EJN: Ohtsuki et al., 2012b Neuron; Ohtsuki & Hansel, 2018 iScience). Further, he found the compartmentalization and clustering modulation of synaptic input on dendrites (Ohtsuki, 2020, J Neurosci). In the visual cortex, using the multi-photon imaging system, he revealed the similarity in the visual function among clonally-related neurons (Ohtsuki et al., 2012a Neuron). He has also found the mechanisms of the acute inflammation-triggered plasticity in the cerebellum, and modulation of the behavior and brain activity, which was recovered by the suppression of aberrant immunity via microglia (Yamamoto et al. / Ohtsuki, 2019 Cell Rep; Ohtsuki et al., 2020 FEBS journal) and stress exposure (Kawatake-Kuno et al., 2024 Neuron; Hikosaka et al., 2025 Comm Biol). His current research focuses on the involvement of the cerebellum in higher-order cognition and its relevance to psychiatric disorders, from the perspectives of neuroscience, glioinflammation, and drug discovery. He also addresses spatial proteomics and multi-omics approaches in translational mouse models and human specimens (Hikosaka et al., 2025, Comm Biol) to advance AI/generative AI–driven therapeutic applications for psychiatric disorders and neurodegenerative diseases. We welcome your participation in our research. If you are interested, please contact us. (ohtsuki.gen.7w[at]kyoto-u.ac.jp).