Present work: 1-Clinical Head of Pathology Department, Instituto Valenciano de Oncología, Valencia. Spain, 2. Pathology Department, Patologika Laboratory, Hospital QuironSalud, Valencia. 3. Associate Professor, Pathology Department, University of Valencia. Summarized: I have been working as a histopathologist at Instituto Valenciano de Oncología, Valencia since 2011. I am part of a large, multidisciplinary team at Pathology Department of IVO that focuses on the management of gastrointestinal tumors and soft tissue tumors. My research interest mainly at pathology Department of Valencia University involves the study of phenotypic and genomic alterations in bone and soft tissue sarcomas, including the translocation associated and genetically complex sarcomas such as Ewing sarcomas, Ewing-like sarcomas and other adult and pediatric mesenchymal tumors. Other research interests include investigating rectal cancer and colon cancer, differential diagnosis and sub-classification of sarcomas, evaluation of histopathological response after chemotherapy in rectal tumors, tumor genetics and biomarkers as well as translational oncology. Our working group has published a number of publications and I am a reviewer for various international journals in the field of surgical pathology. Member of the Real Academia de Medicina, Comunidad Valenciana. Premio RAMCV/ FINCIVO, 2022. Angiosarcoma Expertise and research areas: Bone and soft tissue pathology, gastrointestinal pathology, pathology, Ewing sarcoma, small round cell tumor. Society Member: European Society of Pathology, Spanish Group of study on Gastrointestinal Cancer, Spanish Group of research in Sarcomas, Spanish Group of Research in Lymphomas, Spanish Society of Pathology, Latino-American Society of Pathology. Member of the Board committee of the International International Bone and Soft tissue Tumor Society. List of international publications: please click the following link: https://www.researchgate.net/profile/Isidro_Machado/publications or https://pubmed.ncbi.nlm.nih.gov/?term=machado%20isidro&page=13 Project participation: 1-Prognostic relevance of selected promising predictive markers in classical Ewing’s sarcoma versus peripheral neuroectodermal tumours. PROTHETS Principal Researcher: A Llombart-Bosch. European Union: 503036 2-European Network to Promote Research into Uncommon cancers in adults and childrens: Pathology, Biology and Genetics of bone tumors EuroBoNeT. Principal Researcher: A Llombart-Bosch. European Union: 018814 2 369d3b1905aca4a1c72a09ea77cf0d0d 5-IMPERAS project (Central review of sarcomas diagnosed in Spain). 6-RIA trial in rectal cancer: GEMCAD1402. Induction treatment with FOLFOX with or without Aflibercept, followed by chemo-radiotherapy in locally advanced rectal adenocarcinoma of high risk. An open trial, phase II randomized. Coordinator of the pathological study within the RIA trial. 7-Azur and PIER Rectal Cancer Trial Editorial board: International Journal of Surgical Pathology (Associated Editor), Virchow archive of Pathology, Diagnostic Pathology, Pathology Research and Practice, Artificial Intelligence in Cancer; SM Journal of Case Reports (Associated editor); Modern Applied Science; World Journal of Gastroenterology (Academic Editor). Coordinator Educational Sarcoma Session (45 sessions so far) within IMPERAS project with guest speakers from USA, UK, Europe, Asia (Japan, China, South Korea), Australia, New Zealand Canada and Latin-American