Journal Article Epublish 45 citations
PubMed: 32752267 DOI: 10.3390/jcm9082478
Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality.
J Clin Med 9(8)
Authors: Lisa Boucret, Pierre-Emmanuel Bouet, Jérémie Riou, Guillaume Legendre, Léa Delbos, Hady El Hachem, Philippe Descamps, Pascal Reynier, Pascale May-Panloup
Affiliations
- Reproductive Biology Unit, Angers University Hospital, 49000 Angers, France.
- Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France.
- MINT, Angers University, INSERM 1066, CNRS 6021, IBS-CHU, 49000 Angers, France.
- Department of Reproductive Medicine, Saint Joseph Fertility Center, 1100 Beirut, Lebanon.
- Department of Biochemistry and Genetics, Angers University Hospital, 49000 Angers, France.
Abstract
Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66-1.12]; = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups ( = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.
MeSH
Endometriosis, Birth Rate, Parturition, Ovary, Oocytes, Live Birth
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- Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes. Reprod Biol Endocrinol, 2022
- Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate. Front Endocrinol (Lausanne), 2021
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