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Journal Article Ppublish 10 citations

PubMed: 33504213 DOI: 10.1080/09603123.2021.1879741

Blood biochemical parameters for assessment of COVID-19 in diabetic and non-diabetic subjects: a cross-sectional study.

Int J Environ Health Res 32(6):1344-1358

Authors: Syeda Umme Fahmida Malik, Parveen Afroz Chowdhury, Al Hakim, Mohammad Shahidul Islam, Md Jahangir Alam, Abul Kalam Azad

Affiliations

  • Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh. Department of Biochemistry, North East Medical College Hospital, Sylhet, Bangladesh.
  • Department of Dermatology, Sylhet Women's Medical College Hospital, Sylhet, Bangladesh.
  • Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
  • Department of Statistics, School of Physical Sciences, Shahjalal University of Science & Technology, Sylhet, Bangladesh.

Abstract

This study aims to identify blood biomarkers for rapidly predicting progression and severity assessment of COVID-19 in type 2 diabetic (DM) and non-DM (NDM) patients. Among 211 hospitalized patients suspected of COVID-19, 98 were confirmed COVID-19 by rRT-PCR. The COVID-19 positive group contained 58 DM and 40 NDM patients with total death 9 of which 7 were males and 6 were DM, indicating males and DM individuals as more susceptible to COVID-19. Blood biomarkers notably serum ferritin, CRP, D-dimer, ALT, troponin I, and Hb1Ac were significantly (p < 0.05) higher in COVID-19 patients. Ferritin and HbA1c levels were significantly (p < 0.05) higher in DM than NDM COVID-19 patients. The present study suggests that ferritin and HbA1c levels for DM patients, and ferritin, D-dimer, ALT for NDM patients could be routinely used as biomarkers for progression and severity assessment of COVID-19. CRP and Troponin-I could be the predictor only for poor prognosis of COVID-19.

MeSH

Diabetes Mellitus, Environmental Exposure, Cross-Sectional Studies, Blood, Occupational Health, Biomarkers, Covid-19, Ferritins, Environmental Health

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