Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Ppublish 16 citations
PubMed: 33764427 DOI: 10.1115/1.4050647
Blood Flow Velocimetry in a Microchannel During Coagulation Using Particle Image Velocimetry and Wavelet-Based Optical Flow Velocimetry.
J Biomech Eng 143(9)
Authors: E Kucukal, Y Man, Umut A Gurkan, B E Schmidt
Affiliations
- Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106.
- Warren E. Rupp Associate Professor Department of Mechanical and Aerospace Engineering, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106; Department of Biomedical Engineering, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.
Abstract
This article describes novel measurements of the velocity of whole blood flow in a microchannel during coagulation. The blood is imaged volumetrically using a simple optical setup involving a white light source and a microscope camera. The images are processed using particle image velocimetry (PIV) and wavelet-based optical flow velocimetry (wOFV), both of which use images of individual blood cells as flow tracers. Measurements of several clinically relevant parameters such as the clotting time, decay rate, and blockage ratio are computed. The high-resolution wOFV results yield highly detailed information regarding thrombus formation and corresponding flow evolution that is the first of its kind.
MeSH
Wavelet Analysis, Optic Flow, Blood Circulation
Cited by
- Manual and Automatic Image Analysis Segmentation Methods for Blood Flow Studies in Microchannels. Micromachines (Basel), 2021
- Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology. Membranes (Basel), 2022
- A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease. Biosens Bioelectron, 2022
- Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate. Micromachines (Basel), 2022
- Micro-particle image velocimetry for blood flow in thick round glass micro-channels: Channel fabrication and velocity profile characterization. MethodsX, 2023