Journal Article Research Support, N.I.H., Extramural Ppublish 20 citations
PubMed: 34531078 DOI: 10.1016/j.vaccine.2021.08.092
Association of Flu specific and SARS-CoV-2 specific CD4 T cell responses in SARS-CoV-2 infected asymptomatic heath care workers.
Vaccine 39(41):6019-6024
Authors: Suresh Pallikkuth, Erin Williams, Rajendra Pahwa, Michael Hoffer, Savita Pahwa
Affiliations
- Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
- Department of Otolaryngology, University of Miami Miller School of Medicine, FL 33136, USA.
- Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Abstract
Influenza vaccination is widely advocated to avoid infection with influenza virus, a serious respiratory pathogen, and this was greatly emphasized during the raging COVID-19 epidemic. We conducted a study for baseline Flu specific immunity in a group of health care workers with documented past SARs-CoV-2 infection (designated COVID+) with mild or no symptoms and compared them with a control group that had not been infected with SARS CoV-2 (COVID-). Concurrently, we examined flu and SARS-CoV-2 specific T cell responses using the AIM (activation induced molecules) assay by flow cytometry. All COVID+Â and 40% COVID- participants exhibited AIM responses to SARS-CoV-2 peptides, but only COVID+Â were positive for SARs-CoV-2 antibody. Influenza HIN1 antigen specific CD4 T cells were found in 92% COVID+Â and 76% COVID- participants and exhibited a strong direct correlation with SARS-CoV-2 specific CD4 T cells. This observation suggests that influenza specific T cell immunity may impact immune responses to SARS-CoV-2.
MeSH
Cells, Sars-Cov-2, Vaccines, Covid-19, Influenza, Human, Immunity, Severe Acute Respiratory Syndrome-Related Coronavirus, T-Lymphocytes, Infections
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