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Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish 17 citations

PubMed: 35080734 DOI: 10.1007/s12975-021-00983-5

Test-retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease.

Transl Stroke Res 13(4):583-594

Authors: Lauren R Binnie, Mathilde M H Pauls, Philip Benjamin, Mohani-Preet K Dhillon, Shai Betteridge, Brian Clarke, Rita Ghatala, Fearghal A H Hainsworth, Franklyn A Howe, Usman Khan, Christina Kruuse, Jeremy B Madigan, Barry Moynihan, Bhavini Patel, Anthony C Pereira, Egill Rostrup, Anan B Y Shtaya, Catherine A Spilling, Sarah Trippier, Rebecca Williams, Jeremy D Isaacs, Thomas R Barrick, Atticus H Hainsworth

Affiliations

  • Molecular & Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
  • Department of Neurology, St George's University Hospitals NHS Foundation Trust London, London, UK.
  • Department of Neuroradiology, St George's University Hospitals NHS Foundation Trust London, London, UK.
  • Department of Neuropsychology, St George's University Hospitals NHS Foundation Trust London, London, UK.
  • Department of Neurology and Neurovascular Research Unit, Herlev Gentofte Hospital, Herlev, Denmark.
  • Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
  • Mental Health Centre, University of Copenhagen, Glostrup, Denmark.
  • South London Stroke Research Network, St George's Hospital, London, UK.
  • Molecular & Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
  • Department of Neurology, St George's University Hospitals NHS Foundation Trust London, London, UK.

Abstract

Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment. Cerebral blood flow (CBF) is reduced in SVD, particularly within white matter.Here we quantified test-retest reliability in CBF measurements using pseudo-continuous arterial spin labelling (pCASL) in older adults with clinical and radiological evidence of SVD (N=54, mean (SD): 66.9 (8.7) years, 15 females/39 males). We generated whole-brain CBF maps on two visits at least 7 days apart (mean (SD): 20 (19), range 7-117 days).Test-retest reliability for CBF was high in all tissue types, with intra-class correlation coefficient [95%CI]: 0.758 [0.616, 0.852] for whole brain, 0.842 [0.743, 0.905] for total grey matter, 0.771 [0.636, 0.861] for deep grey matter (caudate-putamen and thalamus), 0.872 [0.790, 0.923] for normal-appearing white matter (NAWM) and 0.780 [0.650, 0.866] for WMH (all p<0.001). ANCOVA models indicated significant decline in CBF in total grey matter, deep grey matter and NAWM with increasing age and diastolic blood pressure (all p<0.001). CBF was lower in males relative to females (p=0.013 for total grey matter, p=0.004 for NAWM).We conclude that pCASL has high test-retest reliability as a quantitative measure of CBF in older adults with SVD. These findings support the use of pCASL in routine clinical imaging and as a clinical trial endpoint.All data come from the PASTIS trial, prospectively registered at: https://eudract.ema.europa.eu (2015-001235-20, registered 13/05/2015), http://www.clinicaltrials.gov (NCT02450253, registered 21/05/2015).

MeSH

White Matter, Gray Matter, Blood, Stroke, Brain, Blood Circulation

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