Journal Article Review Research Support, Non-U.S. Gov't Ppublish 16 citations
PubMed: 36284489 DOI: 10.1177/0271678X221135353
Recent advances in arterial spin labeling perfusion MRI in patients with vascular cognitive impairment.
J Cereb Blood Flow Metab 43(2):173-184
Authors: Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Affiliations
- Department of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
- Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany. Medical Image Analysis Center (MIAC) and qbig, Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
- Department of Anesthesiology, Westchester Medical Center, New York Medical College, NY, USA.
- School of Life Sciences, University of Warwick, Coventry, UK.
Abstract
Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients' independent life and may progress to dementia. Vascular cognitive impairment (VCI) encompasses all cerebrovascular pathologies that contribute to cognitive impairment (CI). Moreover, the majority of CI subtypes involve various aspects of vascular dysfunction. Recent research highlights the critical role of reduced cerebral blood flow (CBF) in the progress of VCI, and the detection of altered CBF may help to detect or even predict the onset of VCI. Arterial spin labeling (ASL) is a non-invasive, non-ionizing perfusion MRI technique for assessing CBF qualitatively and quantitatively. Recent methodological advances enabling improved signal-to-noise ratio (SNR) and data acquisition have led to an increase in the use of ASL to assess CBF in VCI patients. Combined with other imaging modalities and biomarkers, ASL has great potential for identifying early VCI and guiding prediction and prevention strategies. This review focuses on recent advances in ASL-based perfusion MRI for identifying patients at high risk of VCI.
MeSH
Neuroimaging, Aging, Cognitive Dysfunction, Dementia, Vascular, Cerebrovascular Circulation, Cognition Disorders, Perfusion Magnetic Resonance Imaging
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