Journal Article Review Epublish 26 citations
PubMed: 35208167 DOI: 10.3390/metabo12020092
Infection Biomarkers Based on Metabolomics.
Metabolites 12(2)
Authors: Rúben Araújo, Luís F N Bento, Tiago A H Fonseca, Cristiana P Von Rekowski, Bernardo Ribeiro da Cunha, Cecília R C Calado
Affiliations
- ISEL-Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, 1959-007 Lisbon, Portugal.
- Medical Urgency Unit, São José Hospital, Centro Hospitalar Universitário de Lisboa Central, 1150-199 Lisbon, Portugal.
- CHRC, CEDOC, NOVA Medical School, NMS, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal.
- CIMOSM-Centro de Investigação em Modelação e Otimização de Sistemas Multifuncionais, ISEL, 1959-007 Lisbon, Portugal.
Abstract
Current infection biomarkers are highly limited since they have low capability to predict infection in the presence of confounding processes such as in non-infectious inflammatory processes, low capability to predict disease outcomes and have limited applications to guide and evaluate therapeutic regimes. Therefore, it is critical to discover and develop new and effective clinical infection biomarkers, especially applicable in patients at risk of developing severe illness and critically ill patients. Ideal biomarkers would effectively help physicians with better patient management, leading to a decrease of severe outcomes, personalize therapies, minimize antibiotics overuse and hospitalization time, and significantly improve patient survival. Metabolomics, by providing a direct insight into the functional metabolic outcome of an organism, presents a highly appealing strategy to discover these biomarkers. The present work reviews the desired main characteristics of infection biomarkers, the main metabolomics strategies to discover these biomarkers and the next steps for developing the area towards effective clinical biomarkers.
MeSH
Infections, Diagnosis, Prognosis, Biomarkers, Therapeutics, Metabolomics
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