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Journal Article Review Research Support, Non-U.S. Gov't Ppublish 27 citations

PubMed: 35231129 DOI: 10.1111/imm.13462

The roles of interleukin-1 receptor accessory protein in certain inflammatory conditions.

Immunology 166(1):38-46

Authors: Ali Zarezadeh Mehrabadi, Nazanin Aghamohamadi, Majid Khoshmirsafa, Azin Aghamajidi, Mohammad Pilehforoshha, Ramin Massoumi, Reza Falak

Affiliations

  • Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
  • Department of Immunology, School of medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Department of Laboratory Medicine, Translational Cancer Research, Faculty of Medicine, Lund University, Lund, Sweden.

Abstract

Interleukin-1 receptor accessory protein (IL-1RAcP) is a member of the immunoglobulin superfamily proteins consisting of soluble and membranous isoforms. IL-1RAcP plays an essential role in the signaling of the IL-1 family cytokines such as IL-1, IL-33 and IL-36, as well as tyrosine kinases FLT3 and C-Kit. IL-1RAcP generally initiates inflammatory signaling pathway through the recruitment of signaling mediators, including MYD88 and IRAK. Chronic inflammation following prolonged signaling of cytokine receptors is a critical process in the pathogenesis of many inflammatory disorders, including autoimmunity, obesity, psoriasis, type 1 diabetes, endometriosis, preeclampsia and Alzheimer's disease. Recently IL-1RAcP aberrant signaling has been considered to play a central role in the pathogenesis of these chronic inflammatory diseases. Targeting IL-1RAcP signaling pathway that was recently considered in clinical trials related to malignancies also indicates its potential as therapeutic target for the inflammatory and autoimmune diseases. This review summarizes the molecular structure, components associated with IL-1RAcP signaling pathways, and their involvement in the pathogenesis of different inflammatory diseases. We will also discuss the effect of IL-1RAcP inhibition for treatment proposes.

MeSH

Cytokines, Allergy And Immunology, Therapeutics, Receptors, Interleukin-1, Interleukin-1 Receptor Accessory Protein

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