Letter Epublish 8 citations
PubMed: 35641916 DOI: 10.1186/s11658-022-00341-9
COVID-19 therapies: do we see substantial progress?
Cell Mol Biol Lett 27(1):42
Authors: Lucyna Matusewicz, Marlena Golec, Aleksander Czogalla, Kazimierz Kuliczkowski, Adam Konka, Joanna Zembala-John, Aleksander F Sikorski
Affiliations
- Department of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, ul. F. Joliot Curie 14a, 50-383, Wrocław, Poland.
- Silesian Park of Medical Technology Kardio-Med Silesia, ul. M. Curie-Skłodowskiej 10c, 41-800, Zabrze, Poland.
- Chair and Department of Medicine and Environmental Epidemiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, H. Jordana 19, 41-800, Zabrze, Poland.
- Acellmed Ltd. M. Curie-Skłodowskiej 10C, 41-800, Zabrze, Poland.
- Research and Development Centre, Regional Specialist Hospital, Kamieńskiego 73a, 51-154, Wroclaw, Poland.
- Acellmed Ltd. M. Curie-Skłodowskiej 10C, 41-800, Zabrze, Poland.
Abstract
The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in almost 400 million confirmed cases and 6 million deaths, not to mention unknown long-term or persistent side effects in convalescent individuals. In this short review, we discuss approaches to treat COVID-19 that are based on current knowledge of the mechanisms of viral cell receptor recognition, virus-host membrane fusion, and inhibition of viral RNA and viral assembly. Despite enormous progress in antiviral therapy and prevention, new effective therapies are still in great demand.
MeSH
Biochemistry, Molecular Biology, Biophysics, Physiology, Cells, Therapeutics, Rna, Viral, Coronavirus, Covid-19, Sars-Cov-2
Cited by
- Development of Stable, Maleimide-Functionalized Peptidoliposomes Against SARS-CoV-2. Int J Mol Sci, 2025
- The Challenge of Long COVID-19 Management: From Disease Molecular Hallmarks to the Proposal of Exercise as Therapy. Int J Mol Sci, 2022
- Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions. Cell Mol Biol Lett, 2022
- Decoding epitranscriptomic regulation of viral infection: mapping of RNA N-methyladenosine by advanced sequencing technologies. Cell Mol Biol Lett, 2024