Journal Article Review Video-Audio Media Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Epublish 42 citations
PubMed: 35701831 DOI: 10.1186/s40168-022-01262-7
The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine.
Microbiome 10(1):93
Authors: Kelly M Herremans, Andrea N Riner, Miles E Cameron, Kelley L McKinley, Eric W Triplett, Steven J Hughes, Jose G Trevino
Affiliations
- Department of Surgery, University of Florida College of Medicine, P.O. Box 100286, Gainesville, FL, 32610, USA.
- Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Gainesville, FL, 32611-0700, USA.
- Division of Surgical Oncology, Virginia Commonwealth University, 1200 E Broad St, Richmond, VA, 23298-0645, USA.
Abstract
Pancreatic cancer is a deadly disease with limited diagnostic and treatment options. Not all populations are affected equally, as disparities exist in pancreatic cancer prevalence, treatment and outcomes. Recently, next-generation sequencing has facilitated a more comprehensive analysis of the human oral microbiome creating opportunity for its application in precision medicine. Oral microbial shifts occur in patients with pancreatic cancer, which may be appreciated years prior to their diagnosis. In addition, pathogenic bacteria common in the oral cavity have been found within pancreatic tumors. Despite these findings, much remains unknown about how or why the oral microbiome differs in patients with pancreatic cancer. As individuals develop, their oral microbiome reflects both their genotype and environmental influences. Genetics, race/ethnicity, smoking, socioeconomics and age affect the composition of the oral microbiota, which may ultimately play a role in pancreatic carcinogenesis. Multiple mechanisms have been proposed to explain the oral dysbiosis found in patients with pancreatic cancer though they have yet to be confirmed. With a better understanding of the interplay between the oral microbiome and pancreatic cancer, improved diagnostic and therapeutic approaches may be implemented to reduce healthcare disparities. Video Abstract.
MeSH
Microbiological Phenomena, Therapeutics, Pancreatic Neoplasms, Precision Medicine, Environmental Microbiology, High-Throughput Nucleotide Sequencing, Oral Microbiome
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- PM-CNN: microbiome status recognition and disease detection model based on phylogeny and multi-path neural network. Bioinform Adv, 2024
- Biosynthesis of mitis group streptococcal glycolipids and their roles in physiology and antibiotic susceptibility. bioRxiv, 2024
- From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia. Microorganisms, 2022
- Pancreatic Ductal Adenocarcinoma and Nutrition: Exploring the Role of Diet and Gut Health. Nutrients, 2023
- Could there be an interplay between periodontal changes and pancreatic malignancies? World J Clin Cases, 2023
- The Contribution of the Human Oral Microbiome to Oral Disease: A Review. Microorganisms, 2023
- Metagenomic Study Reveals Phage-Bacterial Interactome Dynamics in Gut and Oral Microbiota in Pancreatic Diseases. Int J Mol Sci, 2024
- Revolutionising oral organoids with artificial intelligence. Biomater Transl, 2025
- Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study. Sci Rep, 2024
- Unveiling Microbiota Profiles in Saliva and Pancreatic Tissues of Patients with Pancreatic Cancer. Microorganisms, 2025
- Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories. Cell Biol Toxicol, 2025
- A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022). Front Cell Infect Microbiol, 2023
- Alcohol drinking alters oral microbiota to modulate the progression of alcohol-related liver disease. iScience, 2023
- Impact of microbiota-immunity axis in pancreatic cancer management. World J Gastroenterol, 2022
- Comprehensive Review on Pancreatic Head Cancer: Pathogenesis, Diagnosis, and Treatment Challenges in the Quest for Improved Survival. Cureus, 2024