Journal Article Review Research Support, Non-U.S. Gov't Epublish 12 citations
PubMed: 35954162 DOI: 10.3390/cells11152319
Potential Cell-Based and Cell-Free Therapy for Patients with COVID-19.
Cells 11(15)
Authors: Marselina Irasonia Tan, Nayla Majeda Alfarafisa, Popi Septiani, Anggraini Barlian, Mochamad Firmansyah, Ahmad Faizal, Lili Melani, Husna Nugrahapraja
Affiliations
- School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.
- Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Abstract
Since it was first reported, the novel coronavirus disease 2019 (COVID-19) remains an unresolved puzzle for biomedical researchers in different fields. Various treatments, drugs, and interventions were explored as treatments for COVID. Nevertheless, there are no standard and effective therapeutic measures. Meanwhile, mesenchymal stem cell (MSC) therapy offers a new approach with minimal side effects. MSCs and MSC-based products possess several biological properties that potentially alleviate COVID-19 symptoms. Generally, there are three classifications of stem cell therapy: cell-based therapy, tissue engineering, and cell-free therapy. This review discusses the MSC-based and cell-free therapies for patients with COVID-19, their potential mechanisms of action, and clinical trials related to these therapies. Cell-based therapies involve the direct use and injection of MSCs into the target tissue or organ. On the other hand, cell-free therapy uses secreted products from cells as the primary material. Cell-free therapy materials can comprise cell secretomes and extracellular vesicles. Each therapeutic approach possesses different benefits and various risks. A better understanding of MSC-based and cell-free therapies is essential for supporting the development of safe and effective COVID-19 therapy.
MeSH
Stem Cells, Therapeutics, Microscopy, Electron, Scanning Transmission, Tissues, Covid-19, Sars-Cov-2
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