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Publications

Journal Article Research Support, Non-U.S. Gov't Ppublish 39 citations

PubMed: 36005889 DOI: 10.1093/rheumatology/keac487

Standardized nailfold capillaroscopy in children with rheumatic diseases: a worldwide study.

Rheumatology (Oxford) 62(4):1605-1615

Authors: Karin Melsens, Maurizio Cutolo, Dieneke Schonenberg-Meinema, Ivan Foeldvari, Maria C Leone, Yora Mostmans, Valérie Badot, Rolando Cimaz, Joke Dehoorne, Ellen Deschepper, Tracy Frech, Johanna Hernandez-Zapata, Francesca Ingegnoli, Archana Khan, Dorota Krasowska, Hartwig Lehmann, Ashima Makol, Miguel A Mesa-Navas, Malgorzata Michalska-Jakubus, Ulf Müller-Ladner, Laura Nuño-Nuño, Rebecca Overbury, Carmen Pizzorni, Mislav Radic, Divya Ramadoss, Angelo Ravelli, Silvia Rosina, Clara Udaondo, Merlijn J van den Berg, Ariane L Herrick, Alberto Sulli, Vanessa Smith

Affiliations

  • Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
  • Department of Internal Medicine, Ghent University, Ghent, Belgium.
  • Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy.
  • IRCCS San Martino Polyclinic, Genoa, Italy.
  • Department of Pediatric Immunology, Rheumatology and Infectious diseases, Amsterdam University Medical Centres, Amsterdam, Netherlands.
  • Centre for Paediatric and Adolescent Rheumatology, An der Schön Klinik, Hamburg, Germany.
  • Medical and Rheumatological Clinic, S. Maria Hospital, Terni, Italy.
  • Department of Immunology-Allergology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
  • Department of Dermatology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
  • Department of Rheumatology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
  • Pediatric Rheumatology Unit, Gaetano Pini Hospital, Department of Clinical Sciences and Community Health, Research Centre for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.
  • Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium.
  • Department of Public Health and Primary Care, Biostatistics Unit, Ghent University, Ghent, Belgium.
  • Department of Internal Medicine, Division of Rheumatology, University of Utah, Salt Lake City, UT, USA.
  • Salt Lake Veterans Affair Medical Centre, Utah Vascular Research Laboratory, Salt Lake City, UT, USA.
  • Department of Pediatrics, Universidad de Antioquia, Medellín, Colombia.
  • Clinical Rheumatology Unit , Gaetano Pini Hospital, Department of Clinical Sciences and Community Health, Research Centre for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.
  • Department of Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India.
  • Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
  • Department of Pediatrics, University Medicine Gießen, Gießen, Germany.
  • Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
  • Rheumatology Section, Clínica Universitaria Universidad Pontificia Bolivariana, Medellín, Colombia.
  • Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig University, Gießen, Germany.
  • Kerckhoff-Klinik, Bad Nauheim, Germany.
  • Division of Rheumatology, Hospital La Paz, Madrid, Spain.
  • University of Utah, Department of Pediatrics, Division of Pediatric Rheumatology, Salt Lake City, UT, USA.
  • University Hospital Split, Split, Croatia.
  • Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • University of Genoa, Genoa, Italy.
  • Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Pediatric Rheumatology Department, La Paz Children's Hospital, Madrid, Spain.
  • Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.
  • Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  • Unit for Molecular Immunology and Inflammation, Inflammation Research Centre, VIB-Ghent University, Ghent, Belgium.

Abstract

OBJECTIVES

To standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs).

MATERIAL AND METHODS

In consecutive jRMD children and matched HCs from 13 centres worldwide, 16 NVC images per patient were acquired locally and read centrally per international consensus standard evaluation of the EULAR Study Group on Microcirculation in Rheumatic Diseases. A total of 95 patients with JIA, 22 with JDM, 20 with childhood-onset SLE (cSLE), 13 with juvenile SSc (jSSc), 21 with localized scleroderma (lSc), 18 with MCTD and 20 with primary RP (PRP) were included. NVC differences between juvenile subgroups and HCs were calculated through multivariable regression analysis.

RESULTS

A total of 6474 images were assessed from 413 subjects (mean age 12.1 years, 70.9% female). The quantitative NVC characteristics were significantly lower or higher in the following subgroups compared with HCs: for density: lower in jSSc, JDM, MCTD, cSLE and lSc; for dilations: higher in jSSc, MCTD and JDM; for abnormal shapes: higher in JDM and MCTD; for haemorrhages: higher in jSSc, MCTD, JDM and cSLE. The qualitative NVC assessment of JIA, lSc and PRP did not differ from HCs, whereas the cSLE and jSSc, MCTD, JDM and cSLE subgroups showed more non-specific and scleroderma patterns, respectively.

CONCLUSIONS

This analysis resulted from a pioneering registry of NVC in jRMD. The NVC assessment in jRMD differed significantly from HCs. Future prospective follow-up will further elucidate the role of NVC in jRMD.

MeSH

Microcirculation, Rheumatic Diseases, Microscopic Angioscopy, Child

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