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Publications

Journal Article Review Retracted Publication Ppublish 19 citations

PubMed: 36152703 DOI: 10.1016/j.ijbiomac.2022.09.105

Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significance.

Int J Biol Macromol 222(Pt A):1538-1550

Authors: Hanieh Shirvani, Hanieh Jafari, Sayyed Sajjad Moravveji, Fatemeh Abbasi Faranghizadeh, Mehrdad Talebi, Jalaledin Ghanavi, Farbod Esfandi, Sajad Najafi, Masomeh Nasiri Moghadam, Poopak Farnia, Seyed Mohsen Aghaei Zarch

Affiliations

  • Biocenter Oulu and Faculity of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
  • E-Health Barakat Company Researcher, Tehran, Iran.
  • E-Health Barakat Company Ceo, Tehran, Iran.
  • Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Department of Medical Genetics, Faculity of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran.
  • Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Agronomy, Faculity of Agriculture, University of Kurdistan, Sanandaj, Iran.
  • Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

The recently developed pathogenic virus, SARS-CoV-2, was found in the Hubei Province, China. Giving rise to a broad spectrum of symptoms, SARS-CoV-2 rapidly spread across the globe, causing multi-systemic and dangerous complications, with death in extreme cases. Thereby, the number of research cases increases every day on preventing infection and treating its resulting damage. Accumulating evidence suggests noncoding RNAs (ncRNAs) are necessary for modifying virus infection and antiviral immune reaction, along with biological processes regulating SARS-CoV-2 and subsequent disease states. Therefore, understanding these mechanisms might provide a further understanding of the pathogenesis and feasible therapy alternatives against SARS-CoV2. Consequently, the molecular biology of SARS-CoV-2, ncRNA's role in its infection, and various RNA therapy tactics against the virus have been presented in this review section.

MeSH

Infections, Therapeutics, Macromolecular Substances, Sars Virus, Rna, Untranslated, Sars-Cov-2

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