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Journal Article Research Support, Non-U.S. Gov't Epublish 39 citations

PubMed: 36335368 DOI: 10.1186/s12967-022-03717-9

Anthocyanin improves kidney function in diabetic kidney disease by regulating amino acid metabolism.

J Transl Med 20(1):510

Authors: Yi-Xi Li, Yong-Ping Lu, Donge Tang, Bo Hu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fan, Kai-Wen Cai, Chun Tang, Yi-Qing Zhang, Ling Hong, Jing-Jing Dong, Bao-Zhang Guan, Liang-Hong Yin, Yong Dai, Wei-Bin Bai, Zhi-Hua Zheng, Ting Zhu

Affiliations

  • Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518020, China. Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, 518020, China.
  • Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518020, China. Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
  • Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, 518020, China.
  • Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
  • Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, 518020, China.
  • Department of Nephrology, Guangzhou First People's Hospital, Guangzhou, 510180, China.
  • Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518020, China.
  • Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, 518020, China.
  • Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, 510632, China.
  • Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518020, China.
  • Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518020, China.

Abstract

BACKGROUND

Diabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food and play an important role in ameliorating hyperglycemia and insulin sensitivity. However, the effects of ANT in DKD are still poorly understood. This study aimed to investigate the effect of ANT (cyanidin-3-O-glucoside [C3G]) on the renal function of DKD, and whether the anti-DKD effect of ANT is related to metabolic pathways.

METHODS

To explore the role of ANT in DKD, we performed the examination of blood glucose, renal function, and histopathology. As for the mechanism, we designed the label-free quantification proteomics and nontargeted metabolomics analysis for kidney and serum. Subsequently, we revealed the anti-DKD effect of ANT through the bioinformatic analysis.

RESULTS

We showed that the fasting blood glucose level (- 6.1 mmol/L, P = 0.037), perimeter of glomerular lesions (- 24.1 μm, P = 0.030), fibrosis score of glomerular (- 8.8%, P = 0.002), and kidney function (Cystatin C: - 701.4 pg/mL, P = 0.043; urine creatinine: - 701.4 mmol/L, P = 0.032) were significantly alleviated in DKD mice after ANT treatment compared to untreated in the 20th week. Further, proteins and metabolites in the kidneys of DKD mice were observed to be dramatically altered due to changes in amino acid metabolism with ANT treatment; mainly, taurine and hypotaurine metabolism pathway was upregulated (P = 0.0001, t value = 5.97). Furthermore, upregulated tryptophan metabolism (P < 0.0001, t value = 5.94) and tyrosine metabolism (P = 0.0037, t value = 2.91) pathways had effects on serum of DKD mice as responsed ANT regulating.

CONCLUSIONS

Our results suggested that prevention of the progression of DKD by ANT could be related to the regulation of amino acid metabolism. The use of dietary ANT may be one of the dietary strategies to prevent and treat DKD.

MeSH

Blood Glucose, Kidney Diseases, Anthocyanins, Biomedical Research, Amino Acids, Taurine, Diabetic Nephropathies, Serum

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