Journal Article Review Research Support, Non-U.S. Gov't Epublish 9 citations
PubMed: 36554881 DOI: 10.3390/ijerph192417000
Iron Deficiency and Deranged Myocardial Energetics in Heart Failure.
Int J Environ Res Public Health 19(24)
Authors: Michał Tkaczyszyn, Krzysztof Michał Górniak, Weronika Hanna Lis, Piotr Ponikowski, Ewa Anita Jankowska
Affiliations
- Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
- Institute of Heart Diseases, University Hospital, 50-566 Wroclaw, Poland.
Abstract
Among different pathomechanisms involved in the development of heart failure, adverse metabolic myocardial remodeling closely related to ineffective energy production, constitutes the fundamental feature of the disease and translates into further progression of both cardiac dysfunction and maladaptations occurring within other organs. Being the component of key enzymatic machineries, iron plays a vital role in energy generation and utilization, hence the interest in whether, by correcting systemic and/or cellular deficiency of this micronutrient, we can influence the energetic efficiency of tissues, including the heart. In this review we summarize current knowledge on disturbed energy metabolism in failing hearts as well as we analyze experimental evidence linking iron deficiency with deranged myocardial energetics.
MeSH
Heart Failure, Environmental Exposure, Iron Deficiencies
Cited by
- Iron in ventricular remodeling and aneurysms post-myocardial infarction. Open Med (Wars), 2024
- SIRT6 mediated histone H3K9ac deacetylation involves myocardial remodelling through regulating myocardial energy metabolism in TAC mice. J Cell Mol Med, 2023
- Pathophysiology and Treatment Opportunities of Iron Deficiency in Heart Failure: Is There a Need for Further Trials? Curr Heart Fail Rep, 2023