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Journal Article Epublish 32 citations

PubMed: 36613442 DOI: 10.3390/foods12010220

Alginate Oligosaccharides Prevent Dextran-Sulfate-Sodium-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Modulating Gut Microbiota.

Foods 12(1)

Authors: Axue Wu, Yuan Gao, Ruotong Kan, Pengfei Ren, Changhu Xue, Biao Kong, Qingjuan Tang

Affiliations

  • College of Food Science and Engineering, Ocean University of China, Qingdao 266100, China.
  • College of Food Science and Engineering, Ocean University of China, Qingdao 266100, China. Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
  • Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200438, China.

Abstract

Alginate oligosaccharides are degradation products of alginate and have attracted increasing attention due to their versatile biological functions. In the present study, C57BL/6 mice were used to assess the ameliorative effects and mechanisms of guluronate oligosaccharides (GAOS), mannuronic oligosaccharides (MAOS), and heterozygous alginate oligosaccharides (HAOS), which are the three alginate oligosaccharides of dextran sulfate sodium (DSS)-induced ulcerative colitis. The study showed that alginate oligosaccharides alleviated pathological histological damage by slowing down weight loss, inhibiting colonic length shortening, and reducing disease activity index (DAI) and histopathological scores. Alginate oligosaccharides modulated the colonic inflammatory response by reducing colonic MPO levels and downregulating the expression of IL-6 and IL-1β. Alginate oligosaccharides reduced intestinal permeability and reversed intestinal barrier damage by increasing the number of goblet cells, decreasing LPS levels, downregulating Bax protein levels, upregulating Bcl-2 protein levels, and enhancing the expression of the E-cadherin. Furthermore, alginate oligosaccharides modulated the composition of the gut microbiota and restored the production of short-chain fatty acids (SCFAs), especially acetate and butyrate. In conclusion, our study provides a scientific basis for the role of alginate oligosaccharides in relieving ulcerative colitis.

MeSH

Microbiota, Fatty Acids, Volatile, Oligosaccharides, Alginates, Dextran Sulfate, Colitis, Ulcerative, Gastrointestinal Microbiome

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