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Journal Article Epublish 18 citations

PubMed: 36936993 DOI: 10.3389/fmolb.2023.1100486

Untargeted analysis in post-COVID-19 patients reveals dysregulated lipid pathways two years after recovery.

Front Mol Biosci 10:1100486

Authors: Yamilé López-Hernández, Juan José Oropeza-Valdez, David Alejandro García Lopez, Juan Carlos Borrego, Michel Murgu, Jorge Valdez, Jesús Adrián López, Joel Monárrez-Espino

Affiliations

  • CONACyT-Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico.
  • Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico.
  • Doctorado en Ciencias Básicas, Universidad Autónoma de Zacatecas, Zacatecas, Mexico.
  • Departamento de Epidemiología, Hospital General de Zona #1 "Emilio Varela Luján", Instituto Mexicano del Seguro Social, Centro, Zacatecas, Mexico.
  • Waters Technologies of Brazil, Alameda Tocantins, Barueri, Brazil.
  • Waters Corporation, Mexico City, Mexico.
  • MicroRNAs and Cancer Laboratory, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Mexico.
  • Department of Health Research, Christus Muguerza del Parque Hospital Chihuahua, University of Monterrey, San Pedro Garza García, Mexico.

Abstract

Similar to what it has been reported with preceding viral epidemics (such as MERS, SARS, or influenza), SARS-CoV-2 infection is also affecting the human immunometabolism with long-term consequences. Even with underreporting, an accumulated of almost 650 million people have been infected and 620 million recovered since the start of the pandemic; therefore, the impact of these long-term consequences in the world population could be significant. Recently, the World Health Organization recognized the post-COVID syndrome as a new entity, and guidelines are being established to manage and treat this new condition. However, there is still uncertainty about the molecular mechanisms behind the large number of symptoms reported worldwide. In this study we aimed to evaluate the clinical and lipidomic profiles (using non-targeted lipidomics) of recovered patients who had a mild and severe COVID-19 infection (acute phase, first epidemic wave); the assessment was made two years after the initial infection. Fatigue (59%) and musculoskeletal (50%) symptoms as the most relevant and persistent. Functional analyses revealed that sterols, bile acids, isoprenoids, and fatty esters were the predicted metabolic pathways affected in both COVID-19 and post-COVID-19 patients. Principal Component Analysis showed differences between study groups. Several species of phosphatidylcholines and sphingomyelins were identified and expressed in higher levels in post-COVID-19 patients compared to controls. The paired analysis (comparing patients with an active infection and 2 years after recovery) show 170 dysregulated features. The relationship of such metabolic dysregulations with the clinical symptoms, point to the importance of developing diagnostic and therapeuthic markers based on cell signaling pathways.

MeSH

Recycling, Signs And Symptoms, Covid-19, Metabolomics, Lipidomics, Epidemics, Infections, Post-Acute Covid-19 Syndrome

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