Journal Article Research Support, Non-U.S. Gov't Ppublish 11 citations
PubMed: 37464589 DOI: 10.1111/cns.14364
Targeting the AKT-P53/CREB pathway with epicatechin for improved prognosis of traumatic brain injury.
CNS Neurosci Ther 30(2):e14364
Authors: Ziheng Wang, Zhichao Lu, Yixun Chen, Chenxing Wang, Peipei Gong, Rui Jiang, Qianqian Liu
Affiliations
- Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China. Centre for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Macau, China.
- Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
- Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China. Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
- Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Abstract
AIMS
The aim of this study was to evaluate the effect of epicatechin, on neurological recovery and neuroinflammation after traumatic brain injury (TBI) to investigate its potential value in clinical practice.
METHODS
TBI model was established in adult rats by CCI method. The effect of epicatechin was evaluated after intraperitoneal injection. Neurological recovery after TBI was assessed by Morris Water Maze, mNSS score, Rotarod test and Adhesive removal test. Protein and gene expression was assessed by Western blot, ELISA, PCR and immunofluorescence. Furthermore, the use of AKT pathway inhibitors blocked the therapeutic effects of epicatechin clarifying AKT-P53/CREB as a potential pathway for the effects of epicatechin.
RESULTS
Administering epicatechin after TBI prevented neuronal death, reduced neuroinflammation, and promoted neurological function restoration in TBI rats. Network pharmacology study suggested that epicatechin may exert its therapeutic benefits through the AKT-P53/CREB pathway CONCLUSION: These results indicate that epicatechin, a monomeric compound derived from tea polyphenols, possesses potent antioxidant and anti-inflammatory properties after TBI. The mechanism may be related to the regulation of the AKT-P53/CREB signal pathway.
MeSH
Central Nervous System Diseases, Genes, P53, Prognosis, Therapeutics, Microglia, Brain Injuries, Traumatic
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