Case Reports Epublish 9 citations
PubMed: 37872927 DOI: 10.7759/cureus.45757
Sporadic Creutzfeldt-Jakob Disease With COVID-19 Infection: A Case Report.
Cureus 15(9):e45757
Authors: Harjinder Singh, Thomas Yura, Vivek Kak
Affiliations
- Internal Medicine, Henry Ford Jackson Hospital, Jackson, USA.
- Internal Medicine, Michigan State University, East Lansing, USA.
- Infectious Disease, Henry Ford Jackson Hospital, Jackson, USA.
Abstract
Creutzfeldt-Jakob disease (CJD) is a rare and rapidly fatal neurological disease. Diagnosis is made through clinical features, imaging, electroencephalography, and cerebrospinal fluid analysis. Sporadic CJD accounts for the majority of cases and occurs due to somatic mutation in the gene or random structural change in the prion protein. Coronavirus disease 2019 (COVID-19) is known to cause neurodegeneration, and CJD acceleration is hypothesized due to systemic inflammatory response and prion misfolding. We present a 70-year-old lady with rapidly progressing dementia diagnosed as CJD, with the onset coinciding with COVID-19 infection.
MeSH
Genes, Dementia, Prions, Covid-19, Brain Diseases, Creutzfeldt-Jakob Syndrome, Infections
Cited by
- From long COVID to neurodegeneration. Brain Circ, 2025
- Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study. Open Forum Infect Dis, 2024
- Creutzfeldt-Jakob Disease in a Saudi Female: A Case Report. Cureus, 2025