Journal Article Review Ppublish 4 citations
PubMed: 37878185 DOI: 10.1007/s12079-023-00788-1
Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction.
J Cell Commun Signal 17(4):1131-1143
Authors: Zengbin Wang, Nanhong Tang
Affiliations
- Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
- Department of Hepatobiliary Surgery, Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Abstract
Interleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization signal and a homeodomain (a structure resembling a helix-turn-helix) that can bind to nuclear chromatin. Research has revealed that IL-33 can function as a nuclear factor to regulate various biological processes. This review discusses the cellular localization, functional effects, and immune regulation of full length IL-33 (FLIL-33), cytokine IL-33 (sIL-33) and nuclear IL-33 (nIL-33). In addition, the post-translational modifications of nIL-33 and the hypothesis of using nIL-33 as a treatment method were also summarized. A multidisciplinary approach is required which integrates methods and techniques from genomics, proteomics, cell biology and immunology to provide comprehensive insights into the function and therapeutic potential of nIL-33.
MeSH
Cytokines, Cells, Chromatin, Signal Transduction, Therapeutics, Interleukin-33
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