Journal Article Research Support, Non-U.S. Gov't Epublish 3 citations
PubMed: 37896766 DOI: 10.3390/v15101987
Hybrid Immunity Results in Enhanced and More Sustained Antibody Responses after the Second Sinovac-CoronaVac Dose in a Brazilian Cohort: DETECTCoV-19 Cohort.
Viruses 15(10)
Authors: Bárbara Batista Salgado, Aguyda Rayany Cavalcante Barbosa, Ana Ruth Arcanjo, Daniel Barros de Castro, Tatyana Costa Amorim Ramos, Felipe Naveca, Daniel M Altmann, Rosemary J Boyton, Jaila Dias Borges Lalwani, Pritesh Lalwani
Affiliations
- Instituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Rua Terezina, 476 Adrianópolis, Manaus 69057-070, AM, Brazil.
- Laboratory of Infectious Diseases and Immunology, ILMD/Fiocruz Amazônia and PPGIBA/ICB-UFAM, Manaus 69080-900, AM, Brazil.
- Fundação de Vigilância em Saúde do Amazonas (FVS/AM), Manaus 69093-018, AM, Brazil.
- Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK.
- Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London SW3 6LY, UK.
- Department of Infectious Disease, Imperial College London, London W12 0NN, UK.
- Faculdade de Ciências Farmacêuticas (FCF), Universidade Federal do Amazonas (UFAM), Manaus 69080-900, AM, Brazil.
Abstract
We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case-control study performed in CoronaVac-immunized individuals participating in a longitudinal prospective study of adults in Manaus (DETECTCoV-19). Antibody responses were measured by standard serological immunoassays. Peak anti-S-RBD and neutralizing RBD-ACE2 blocking antibody responses after two doses of CoronaVac vaccine were similar in vaccine breakthrough cases (n = 9) and matched controls (n = 45). Individuals with hybrid immunity resulting from prior SARS-CoV-2 infection followed by vaccination (n = 22) had elevated levels of anti-N, anti-S-RBD and RBD-ACE2 blocking antibodies after the second vaccine dose compared to infection-naïve individuals (n = 48). Post-vaccination SARS-CoV-2-specific antibody responses rapidly waned in infection-naïve individuals. Antibody responses wane after vaccination, making individuals susceptible to infection by SARS-CoV-2 variants. These findings support the need for booster doses after primary vaccination. Population antibody serosurveys provide critical information toward implementing optimal timing of booster doses.
MeSH
Antibody Formation, Vaccines, Virology, Vaccination, Immunity, Infections
Cited by
- Re-Evaluation and Retrospective Comparison of Serum Neutralization Induced by Three Different Types of Inactivated SARS-CoV-2 Vaccines. Vaccines (Basel), 2024
- Low Antibody-Dependent Enhancement of Viral Entry Activity Supports the Safety of Inactivated SARS-CoV-2 Vaccines. Vaccines (Basel), 2025
- A 20-month longitudinal study to evaluate humoral and cellular immunity after COVID-19 vaccines. Mem Inst Oswaldo Cruz, 2025