Review Journal Article Ppublish 16 citations
PubMed: 37934800 DOI: 10.1210/endrev/bnad032
Diabetes Mellitus, Energy Metabolism, and COVID-19.
Endocr Rev 45(2):281-308
Authors: Caterina Conte, Elisa Cipponeri, Michael Roden
Affiliations
- Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome 00166, Italy.
- Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan 20099, Italy.
- Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf 40225, Germany.
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf 40225, Germany.
- German Center for Diabetes Research, Partner Düsseldorf, Neuherberg 85764, Germany.
Abstract
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because they are not only risk factors for both acute and chronic COVID-19 manifestations, but also because COVID-19 alters energy metabolism. Such metabolic alterations can lead to dysglycemia and long-lasting effects. Thus, the COVID-19 pandemic has the potential for a further rise of the diabetes pandemic. This review outlines how preexisting metabolic alterations spanning from excess visceral adipose tissue to hyperglycemia and overt diabetes may exacerbate COVID-19 severity. We also summarize the different effects of SARS-CoV-2 infection on the key organs and tissues orchestrating energy metabolism, including adipose tissue, liver, skeletal muscle, and pancreas. Last, we provide an integrative view of the metabolic derangements that occur during COVID-19. Altogether, this review allows for better understanding of the metabolic derangements occurring when a fire starts from a small flame, and thereby help reducing the impact of the COVID-19 pandemic.
MeSH
Infections, Adipose Tissue, Endocrinology, Liver, Muscle, Skeletal, Pancreas, Diabetes Mellitus, Tissues, Pandemics, Covid-19, Sars-Cov-2
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- Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes. BMJ Open Diabetes Res Care, 2025
- Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study. PLoS One, 2024
- Energy metabolism in health and diseases. Signal Transduct Target Ther, 2025
- Sex differences in patients with COVID-19 after bariatric surgery: a multicenter cross-sectional study. Front Public Health, 2024