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Publications

Journal Article Review Epublish 9 citations

PubMed: 38002006 DOI: 10.3390/biomedicines11113006

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus.

Biomedicines 11(11)

Authors: Alessia Valentini, Carmine Cardillo, David Della Morte, Manfredi Tesauro

Affiliations

  • Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.
  • Department of Aging, Policlinico A. Gemelli IRCCS, 00168 Roma, Italy.
  • Department of Translational Medicine and Surgery, Catholic University, 00168 Rome, Italy.

Abstract

Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.

MeSH

Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Tissues, Noncommunicable Diseases

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