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Journal Article Review Epublish 7 citations

PubMed: 38138143 DOI: 10.3390/microorganisms11122999

The Role of in Liver Diseases: A Systematic Review of Next-Generation Sequencing Studies.

Microorganisms 11(12)

Authors: Gabriel Henrique Hizo, Pabulo Henrique Rampelotto

Affiliations

  • Graduate Program in Gastroenterology and Hepatology Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
  • Bioinformatics and Biostatistics Core Facility, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-907, Brazil.

Abstract

The physiopathology of liver diseases is complex and can be caused by various factors. is a bacterial genus commonly found in the human gut microbiome and has been shown to influence the development of different stages of liver diseases significantly. This study investigated the relationship between the genus and liver injury. In this work, we performed a systematic review in major databases using the key terms "Bifidobacterium", "ALD", "NAFLD", "NASH", "cirrhosis", and "HCC" to achieve our purpose. In total, 31 articles were selected for analysis. In particular, we focused on studies that used next-generation sequencing (NGS) technologies. The studies focused on assessing levels in the diseases and interventional aimed at examining the therapeutic potential of in the mentioned conditions. Overall, the abundance of was reduced in hepatic pathologies. Low levels of were associated with harmful biochemical and physiological parameters, as well as an adverse clinical outcome. However, interventional studies using different drugs and treatments were able to increase the abundance of the genus and improve clinical outcomes. These results strongly support the hypothesis that changes in the abundance of significantly influence both the pathophysiology of hepatic diseases and the related clinical outcomes. In addition, our critical assessment of the NGS methods and related statistical analyses employed in each study highlights concerns with the methods used to define the differential abundance of , including potential biases and the omission of relevant information.

MeSH

Liver Diseases, Alcoholic, Microbiota, Therapeutics, Carcinoma, Hepatocellular, High-Throughput Nucleotide Sequencing, Non-Alcoholic Fatty Liver Disease

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