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Publications

Journal Article Review Epublish 10 citations

PubMed: 38398748 DOI: 10.3390/life14020239

The Impact of Probiotic on Liver Diseases and the Microbiota.

Life (Basel) 14(2)

Authors: Gabriel Henrique Hizo, Pabulo Henrique Rampelotto

Affiliations

  • Graduate Program in Gastroenterology and Hepatology Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
  • Bioinformatics and Biostatistics Core Facility, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-907, Brazil.

Abstract

Recent studies have shown the promising potential of probiotics, especially the bacterial genus , in the treatment of liver diseases. In this work, a systematic review was conducted, with a focus on studies that employed advanced Next Generation Sequencing (NGS) technologies to explore the potential of as a probiotic for treating liver pathologies such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Alcoholic Liver Disease (ALD), Cirrhosis, and Hepatocelullar Carcinoma (HCC) and its impact on the microbiota. Our results indicate that is a safe and effective probiotic for treating liver lesions. It successfully restored balance to the intestinal microbiota and improved biochemical and clinical parameters in NAFLD, ALD, and Cirrhosis. No significant adverse effects were identified. While more research is needed to establish its efficacy in treating NASH and HCC, the evidence suggests that is a promising probiotic for managing liver lesions.

MeSH

Liver Diseases, Carcinoma, Hepatocellular, Non-Alcoholic Fatty Liver Disease, Liver Diseases, Alcoholic, Microbiology, Liver, Probiotics, Wounds And Injuries, Microbiota

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