Journal Article Comparative Study Ppublish
PubMed: 39468772 DOI: 10.1111/eci.14339
Comparative assessment of phenotypic markers in patients with chronic inflammation: Differences on Bifidobacterium concerning liver status.
Eur J Clin Invest 55(2):e14339
Authors: Lourdes Chero-Sandoval, Andrea Higuera-Gómez, María Martínez-Urbistondo, Raquel Castejón, Susana Mellor-Pita, Víctor Moreno-Torres, Daniel de Luis, Amanda Cuevas-Sierra, J Alfredo Martínez
Affiliations
- Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, Spain.
- Department of Endocrinology and Nutrition, University Clinical Hospital, University of Valladolid, Valladolid, Spain.
- Internal Medicine Service, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.
- Health Sciences School and Medical Centre, International University of the Rioja (UNIR), Madrid, Spain.
- Centre of Endocrinology and Nutrition, University of Valladolid, Valladolid, Spain.
- Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, Spain. Centre of Endocrinology and Nutrition, University of Valladolid, Valladolid, Spain. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain.
Abstract
BACKGROUND
The relationship between systemic lupus erythematosus (SLE) and low-grade metabolic inflammation (MI) with the microbiota is crucial for understanding the pathogenesis of these diseases and developing effective therapeutic interventions. In this context, it has been observed that the gut microbiota plays a key role in the immune regulation and inflammation contributing to the exacerbation through inflammatory mediators. This research aimed to describe similarities/differences in anthropometric, biochemical, inflammatory, and hepatic markers as well as to examine the putative role of gut microbiota concerning two inflammatory conditions: SLE and MI.
METHODS
Data were obtained from a cohort comprising adults with SLE and MI. Faecal samples were determined by 16S technique. Statistical analyses compared anthropometric and clinical variables, and LEfSe and MetagenomeSeq were used for metagenomic data. An interaction analysis was fitted to investigate associations of microbiota with fatty liver index (FLI) depending on the inflammatory condition.
RESULTS
Participants with low-grade MI showed worse values in anthropometry and biochemicals compared with patients with SLE. The liver profile of patients with MI was unhealthier, while no relevant differences were found in most of the inflammatory markers between groups. LEfSe analysis revealed an overrepresentation of Bifidobacteriaceae family in SLE group. An interactive association between gut Bifidobacterium abundance and type of disease was identified for FLI values, suggesting an effect modification of the gut microbiota concerning liver markers depending on the inflammatory condition.
CONCLUSION
This study found phenotypical and microbial similarities and disparities between these two inflammatory conditions, evidenced in clinical and hepatic markers, and showed the interactive interplay between gut Bifidobacterium and liver health (measured by FLI) that occur in a different manner depending on the type of inflammatory disease. These results underscore the importance of personalized approaches and individual microbiota in the screening of different inflammatory situations, considering unique hepatic and microbiota profiles.
MeSH
Liver, Lupus Erythematosus, Systemic, Bifidobacterium, Gastrointestinal Microbiome, Microbiota