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Journal Article Review Epublish 19 citations

PubMed: 38256075 DOI: 10.3390/ijms25021001

Metal-Based Nanoparticles for Cardiovascular Diseases.

Int J Mol Sci 25(2)

Authors: Alexandru Scafa Udriște, Alexandra Cristina Burdușel, Adelina-Gabriela Niculescu, Marius Rădulescu, Alexandru Mihai Grumezescu

Affiliations

  • Department 4 Cardio-Thoracic Pathology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.
  • Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
  • Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, 1-7 Polizu St. 011061 Bucharest, Romania.

Abstract

Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. While there are many therapeutic alternatives available for the management of CVDs, the majority of classic therapeutic strategies were found to be ineffective at stopping or significantly/additionally slowing the progression of these diseases, or they had unfavorable side effects. Numerous metal-based nanoparticles (NPs) have been created to overcome these limitations, demonstrating encouraging possibilities in the treatment of CVDs due to advancements in nanotechnology. Metallic nanomaterials, including gold, silver, and iron, come in various shapes, sizes, and geometries. Metallic NPs are generally smaller and have more specialized physical, chemical, and biological properties. Metal-based NPs may come in various forms, such as nanoshells, nanorods, and nanospheres, and they have been studied the most. Massive potential applications for these metal nanomaterial structures include supporting molecular imaging, serving as drug delivery systems, enhancing radiation-based anticancer therapy, supplying photothermal transforming effects for thermal therapy, and being compounds with bactericidal, fungicidal, and antiviral qualities that may be helpful for cardiovascular diseases. In this context, the present paper aims to review the applications of relevant metal and metal oxide nanoparticles in CVDs, creating an up-to-date framework that aids researchers in developing more efficient treatment strategies.

MeSH

Cardiovascular Diseases, Therapeutics, Nanoparticles, Nanostructures, Nanomedicine

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