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Journal Article Review Ppublish 5 citations

PubMed: 38813571 DOI: 10.1007/s40475-024-00318-y

Genomics - Current Understanding, Advances, and Applications.

Curr Trop Med Rep 11(2):92-103

Authors: Fiifi Agyabeng-Dadzie, Rui Xiao, Jessica C Kissinger

Affiliations

  • Department of Genetics, University of Georgia, Athens, GA 30602 USA.
  • Institute of Bioinformatics, University of Georgia, Athens, GA 30602 USA.
  • Center for Tropical and Emerging Global Diseases, University of Georgia, Coverdell Center, 107, 500 D.W. Brooks Drive, Athens, GA 30602 USA.

Abstract

Purpose of Review

Here we highlight the significant contribution that genomics-based approaches have had on the field of research and the insights these approaches have generated into biology and transmission.

Recent Findings

There are advances in genomics, genetic manipulation, gene expression, and single-cell technologies. New and better genome sequences have revealed variable sub-telomeric gene families and genes under selection. RNA expression data now include single-cell and post-infection time points. These data have provided insights into the life cycle and host-pathogen interactions. Antisense and ncRNA transcripts are abundant. The critical role of the dsRNA virus is becoming apparent.

Summary

The community's ability to identify genomic targets in the abundant, yet still lacking, collection of genomic data, combined with their increased ability to assess function via gene knock-out, is revolutionizing the field. Advances in the detection of virulence genes, surveillance, population genomics, recombination studies, and epigenetics are upon us.

MeSH

Infections, Rna, Cells, Genes, Genomics, Host-Pathogen Interactions

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