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Journal Article Review Ppublish 2 citations

PubMed: 38815251 DOI: 10.1002/adhm.202400475

Imaging-Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids.

Adv Healthc Mater 13(27):e2400475

Authors: Seong-Eun Kim, Suji Yun, Junsang Doh, Hong Nam Kim

Affiliations

  • Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea.
  • Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, South Korea.
  • Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, South Korea. Department of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX institute, Soft Foundry Institute, Seoul National University, Seoul, 08826, South Korea.
  • Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea. Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea. School of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea. Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, 03722, Republic of Korea.

Abstract

Cancer immunotherapy is used to treat tumors by modulating the immune system. Although the anticancer efficacy of cancer immunotherapy has been evaluated prior to clinical trials, conventional in vivo animal and endpoint models inadequately replicate the intricate process of tumor elimination and reflect human-specific immune systems. Therefore, more sophisticated models that mimic the complex tumor-immune microenvironment must be employed to assess the effectiveness of immunotherapy. Additionally, using real-time imaging technology, a step-by-step evaluation can be applied, allowing for a more precise assessment of treatment efficacy. Here, an overview of the various imaging-based evaluation platforms recently developed for cancer immunotherapeutic applications is presented. Specifically, a fundamental technique is discussed for stably observing immune cell-based tumor cell killing using direct imaging, a microwell that reproduces a confined space for spatial observation, a droplet assay that facilitates cell-cell interactions, and a 3D microphysiological system that reconstructs the vascular environment. Furthermore, it is suggested that future evaluation platforms pursue more human-like immune systems.

MeSH

Cells, Neoplasms, Immunotherapy, Organoids, Immune System, Environment

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