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Journal Article Review Ppublish 79 citations

PubMed: 38908072 DOI: 10.1016/j.redox.2024.103211

Ferroptosis in health and disease.

Redox Biol 75:103211

Authors: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M Bebber, Kivanc Birsoy, Jan P Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M DeNicola, Tobias P Dick, Ayelén Distéfano, Scott J Dixon, Jan B Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A Friese, Dominic C Fuhrmann, Ana J García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E Kagan, David B Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V Milton … and 44 other authors

Affiliations

  • Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
  • Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany.
  • Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.
  • Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
  • Department of Pediatrics, Columbia University, New York City, NY, USA.
  • University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
  • Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA.
  • Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany.
  • Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany.
  • Department of Biological Sciences, Columbia University, New York City, NY, USA.
  • Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany.
  • Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany.
  • Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany.
  • College of Life Sciences, Nankai University, Tianjin, China.
  • Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA.
  • Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.
  • Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina.
  • Department of Biology, Stanford University, Stanford, CA, USA.
  • Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany.
  • Department of Immunobiology, Université de Lausanne, Switzerland.
  • Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany.
  • Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany.
  • Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany.
  • Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany.
  • Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
  • Department of Biomedical Sciences, University of Antwerp, Belgium.
  • Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL).
  • College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea.
  • School of Public Health, University of Pittsburgh, PA, USA.
  • Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
  • Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
  • Center for Translational Biomedical Iron Research, Heidelberg University, Germany.
  • Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
  • Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany.
  • Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany.
  • Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany.

Abstract

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.

MeSH

Cells, Ferroptosis, Research, Cell Death, Membranes

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