System Maintenance Notice

Please note that maintenance work is scheduled between 4 AM and 5 AM - CET. During this time, you may experience reduced performance. Thanks for your patience.

Publications

Journal Article Ppublish 21 citations

PubMed: 39079529 DOI: 10.1016/j.neuron.2024.07.002

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.

Neuron 112(19):3252-3266.e5

Authors: Keith R Murphy, Jordan S Farrell, Jonas Bendig, Anish Mitra, Charlotte Luff, Ina A Stelzer, Hiroshi Yamaguchi, Christopher C Angelakos, Mihyun Choi, Wenjie Bian, Tommaso DiIanni, Esther Martinez Pujol, Noa Matosevich, Raag Airan, Brice Gaudillière, Elisa E Konofagou, Kim Butts-Pauly, Ivan Soltesz, Luis de Lecea

Affiliations

  • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Department of Neurosurgery, Stanford University, Stanford, CA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA; F.M. Kirby Neurobiology Center, Harvard Medical School, Boston, MA, USA.
  • Department of Biomedical Engineering, Columbia University, New York, NY, USA.
  • Department of Anesthesia, Stanford University, Stanford, CA, USA.
  • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Department of Neuroscience, Nagoya University, Nagoya, Japan.
  • Department of Radiology, Stanford University, Stanford, CA, USA.
  • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • Department of Radiology, Stanford University, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
  • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Department of Neurosurgery, Stanford University, Stanford, CA, USA.
  • Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Abstract

Focused ultrasound can non-invasively modulate neural activity, but whether effective stimulation parameters generalize across brain regions and cell types remains unknown. We used focused ultrasound coupled with fiber photometry to identify optimal neuromodulation parameters for four different arousal centers of the brain in an effort to yield overt changes in behavior. Applying coordinate descent, we found that optimal parameters for excitation or inhibition are highly distinct, the effects of which are generally conserved across brain regions and cell types. Optimized stimulations induced clear, target-specific behavioral effects, whereas non-optimized protocols of equivalent energy resulted in substantially less or no change in behavior. These outcomes were independent of auditory confounds and, contrary to expectation, accompanied by a cyclooxygenase-dependent and prolonged reduction in local blood flow and temperature with brain-region-specific scaling. These findings demonstrate that carefully tuned and targeted ultrasound can exhibit powerful effects on complex behavior and physiology.

MeSH

Cells, Physiology, Neurons, Hypothalamus, Thalamus, Brain, Optogenetics

Cited by