Journal Article Review Research Support, N.I.H., Extramural Epublish 2 citations
PubMed: 39329738 DOI: 10.3390/cells13181554
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson's Disease.
Cells 13(18)
Authors: Matthew R Miller, Harold E Landis, Robert E Miller, Yousef Tizabi
Affiliations
- NutriGenetic Research Institute, Ephrata, PA 17522, USA.
- Integrative Medicine Fellow, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
- Department of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA.
Abstract
Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important adhesion molecules during leukocyte recruitment. It is encoded by the gene and plays a central role in inflammation. Its crucial role in many inflammatory diseases such as ulcerative colitis and rheumatoid arthritis are well established. Given that neuroinflammation, underscored by microglial activation, is a key element in neurodegenerative diseases such as Parkinson's disease (PD), we investigated whether ICAM-1 has a role in this progressive neurological condition and, if so, to elucidate the underpinning mechanisms. Specifically, we were interested in the potential interaction between ICAM-1, glial cells, and ferroptosis, an iron-dependent form of cell death that has recently been implicated in PD. We conclude that there exist direct and indirect (via glial cells and T cells) influences of ICAM-1 on ferroptosis and that further elucidation of these interactions can suggest novel intervention for this devastating disease.
MeSH
Cells, Tissue Adhesions, Genes, Parkinson Disease, Ferroptosis, Neuroglia, Intercellular Adhesion Molecule-1