Journal Article Review Ppublish 1 citation
PubMed: 39672680 DOI: 10.1016/j.tig.2024.11.006
Keeping it safe: control of meiotic chromosome breakage.
Trends Genet 41(4):315-329
Authors: Adhithi R Raghavan, Andreas Hochwagen
Affiliations
- Department of Biology, New York University, New York, NY 10003, USA.
- Department of Biology, New York University, New York, NY 10003, USA.
Abstract
Meiotic cells introduce numerous programmed DNA double-strand breaks (DSBs) into their genome to stimulate crossover recombination. DSB numbers must be high enough to ensure each homologous chromosome pair receives the obligate crossover required for accurate meiotic chromosome segregation. However, every DSB also increases the risk of aberrant or incomplete DNA repair, and thus genome instability. To mitigate these risks, meiotic cells have evolved an intricate network of controls that modulates the timing, levels, and genomic location of meiotic DSBs. This Review summarizes our current understanding of these controls with a particular focus on the mechanisms that prevent meiotic DSB formation at the wrong time or place, thereby guarding the genome from potentially catastrophic meiotic errors.
MeSH
Cells, Chromosome Breakage, Genetics, Genome, Chromosomes
Cited by
- Distinct chromatin regulators downmodulate meiotic axis formation and DNA break induction at chromosome ends. bioRxiv, 2025
- Bipartite chromatin recognition by Hop1 from two diverged Holozoa. Life Sci Alliance, 2025
- Hurdles of Sperm Success: Exploring the Role of DNases. Int J Mol Sci, 2025